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ALS

Created:   10/20/2011
Contains:  45 items

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Diaphragm Pacing for ALS at a Crossroads Following Conflicting Trial Results

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Endogenous Retrovirus Is Implicated in Neuropathology of Sporadic ALS, Prompting a Pilot Trial of Combination Antiretroviral Therapy

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‘The Tip of a Very Big Iceberg’: Three Research Groups Unravel Mechanism, Defective Nuclear Transport, in ALS

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A Novel Optical Technique for Observing Motor Neurons in Real Time What Researchers Are Learning, What It Could Mean for Regenerative Therapies

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Experimental ALS Drug Triggers Social Media Hype, But Doctors Say Facts about GM604 Are Slim

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A Protein Critical to the Neuromuscular Junction Found in Sera of ALS Patients

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Mayo Lab Develops First Mouse Model of Key Genetic Defect in ALS, FTD

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News from the AAN Annual Meeting: Preclinical Success Reported with Gene Therapy for Spinal Muscular Atrophy

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NEWS FROM THE AAN ANNUAL MEETING: ALS/Frontotemporal Dementia: Transthyretin Offers Gene-Specific Biomarker

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Multiple Rare Variants Contribute to Earlier ALS Onset, New Study Finds

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‘The Theory of Everything’: Stephen Hawking's Story on the Big Screen

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FILM REVIEW: ‘You're Not You’: Trepidation and Alienation in ALS

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C9orF72 RAN Proteins Detected in ALS CSF, Reduced In Vitro with Small Molecules

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ALS Registry Debuts with First Nationwide Prevalence Figure: 12,187 ALS Cases

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NEWS FROM THE AAN ANNUAL MEETING: New Study Asks: What Is the Cost of Multidisciplinary ALS Care?

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White Matter Changes in Pre-Symptomatic ALS

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Stem Cells from ALS Patients Yield New Insights about Disease

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ALS, Through the Eyes of a Filmmaker and Daughter

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Scientists Create Humanized Model of Sporadic ALS

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Why Reducing MMP-9 Could Be a ‘Good Thing’ for ALS

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Leading ALS Researcher and Former AAN President Theodore Munsat, MD, Dies

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Antisense Therapy Against C9ORF72 Looks Promising in ALS Models

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How Does ALS Spread?

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Lessons Learned — and a Roadmap to New Approaches — After Disappointing Phase 3 Results for Two Drugs for ALS

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NEWS FROM THE AAN ANNUAL MEETING: Diaphragm Pacing for ALS Patients: How to Identify Best Candidates

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Moving Forward on a New Therapeutic Target — Oligodendrocytes — for ALS

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New Data Confirm the Role of Inflammatory Markers in ALS

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Oligodendroglia Found to Play a Role in Motor Neuron Death and ALS

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IN THE FIELD: Sheila Essey Awardee Christopher Shaw, MBChB, MD: On Taking the Back Roads to Unraveling ALS Genetics

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NEWS FROM THE AAN ANNUAL MEETING: C9ORF72 Studies Shed Light on the Most Common Genetic Cause of ALS and FTD

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Antisense Therapy for ALS Found Safe in Small Trial, but More Safety Data Are Sought

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News from the AAN Annual Meeting: Common Inflammatory Pathways Identified for ALS Animal Model and Humans With Disease, Suggesting New Therapeutic Targets

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Richard K. Olney, MD, Renowned ALS Researcher Dies of ALS at 64

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Is ALS Ready for a Staging Model?

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Turning Off Mutant TDP-43 Stops ALS in an Animal Model

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Encouraging Phase 2 Results for Dexpramipexole for ALS Prompt Phase 3 Trial

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At Unique ALS Meeting, New Discoveries, Paradigms, and Complexities Are Front and Center

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Is a Diaphragm Pacing System for ALS Ready for Prime Time?

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Major New Gene Discovery Links ALS to Frontotemporal Dementia

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Sporadic ALS Astrocytes are Found Toxic to Motor Neurons

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News from the AAN Annual Meeting: ALS Trial Patients Don't Reflect the General ALS Population: A True Treatment Effect May be Elusive

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Dr. Robert Baloh on Diaphragm Pacing for ALS Patients

Creator: Olga Rukovets
Duration: 7:34
Neurology Today  In a poster presented at the AAN annual meeting last March, researchers reported that three preoperative tests combined with clinical judgment are helpful in predicting diaphragm excitability in amyotrophic lateral sclerosis (ALS) patients. Here, author Robert Baloh, MD, director of neuromuscular medicine in the department of neurology at Cedars-Sinai, talks about the currently available data on the Diaphragm Pacing System in ALS patients and what research still needs to be done.

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Lessons Learned After Phase 3 Trial for ALS Drug Dexpramipexole Fails

Neurology Today

From the AAN Annual Meeting: Is dexpramipexole safe and effective for patients with ALS? In a video interview, Neurology Today’s Editor-in-Chief Steven P. Ringel, MD, and Associate Editor Robert Holloway, MD, discuss the key clinical takeaways from the latest analysis of data on the trial involving dexpramipexole for ALS.

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Diaphragm Pacing for ALS Patients: Who Are the Best Candidates?

Neurology Today May 16, 2013, Volume 13, Issue 10;

In a study presented at the AAN annual meeting last March, researchers reported that three preoperative tests combined with clinical judgment are helpful in predicting diaphragm excitability in amyotrophic lateral sclerosis (ALS) patients. In a video interview, Neurology Today’s Editor-in-Chief Steven P. Ringel, MD, and Associate Editor Robert Holloway, MD, discuss the implications of these findings for ALS experts and patients.

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Antisense Therapy for ALS Found Safe in Small Trial, But More Safety Data Are Sought, From the AAN Annual Meeting

Neurology Today

An antisense oligonucleotide tailored to target part of the messenger RNA of superoxide dismutase 1 (SOD1) was found safe in a small trial involving 21 patients with amyotrophic lateral sclerosis, but the investigators contend they need to do more long-term experiments in animal models of ALS before moving forward. Neurology Today Editor-in-chief Steven P. Ringel, MD, and Associate Editor Robert Holloway, MD discuss the promise and challenges ahead for antisense oligonucleotide therapy for ALS.

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