BACKGROUND: Stereotactic radiosurgery (SRS) of meningiomas is associated with post-treatment peritumoral edema (PTE). OBJECTIVE: The purpose of this study was to evaluate the prevalence and risk factors of post-SRS PTE for intracranial meningiomas. METHODS: A total of 163 patients with 182 meningiomas treated with SRS were retrospectively reviewed. Tumors were divided into 4 pre-SRS groups by whether they had previous surgery and whether they had pre-existing PTE. Several risk factors were investigated by univariate and multivariate analysis. RESULTS: Of 182 tumors, 45 (24.7%) developed post-SRS PTE. Compared to tumors without preexisting PTE, the odds of developing post-SRS PTE in tumors with pre-existing PTE were 5.8 times higher in all tumors, and 6.9 times higher in tumors without previous surgery. CONCLUSION: Tumor-brain contact interface area, and pre-existing PTE were the most significant risk factors for post-SRS PTE.