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Lesion-induced Pseudo-dominance at Functional Magnetic Resonance Imaging: Implications for Preoperative Assessments

Ulmer, John L. M.D.; Hacein-Bey, Lotfi M.D.; Mathews, Vincent P. M.D.; Mueller, Wade M. M.D.; DeYoe, Edgar A. Ph.D.; Prost, Robert W. Ph.D.; Meyer, Glenn A. M.D.; Krouwer, Hendrikus G. M.D.; Schmainda, Kathleen M. Ph.D.

Neurosurgery:
doi: 10.1227/01.NEU.0000134384.94749.B2
Clinical Studies
Abstract

OBJECTIVE: To illustrate how lesion-induced neurovascular uncoupling at functional magnetic resonance imaging (fMRI) can mimic hemispheric dominance opposite the side of a lesion preoperatively.

METHODS: We retrospectively reviewed preoperative fMRI mapping data from 50 patients with focal brain abnormalities to establish patterns of hemispheric dominance of language, speech, visual, or motor system functions. Abnormalities included gliomas (31 patients), arteriovenous malformations (AVMs) (11 patients), other congenital lesions (4 patients), encephalomalacia (3 patients), and tumefactive encephalitis (1 patient). A laterality ratio of fMRI hemispheric dominance was compared with actual hemispheric dominance as verified by electrocortical stimulation, Wada testing, postoperative and posttreatment deficits, and/or lesion-induced deficits. fMRI activation maps were generated with cross-correlation (P < 0.001) or t test (P < 0.001) analysis.

RESULTS: In 50 patients, a total of 85 functional areas were within 5 mm of the edge of a potentially resectable lesion. In 23 of these areas (27%), reduced fMRI signal in perilesional eloquent cortex in conjunction with preserved or increased signal in homologous contralateral brain areas revealed functional dominance opposite the side of the lesion. This suggested possible lesion-induced transhemispheric cortical reorganization to homologous brain regions (homotopic reorganization). In seven patients, however, the fMRI data were inconsistent with other methods of functional localization. In two patients with left inferior frontal gyrus gliomas and in one patient with focal tumefactive meningoencephalitis, fMRI incorrectly suggested strong right hemispheric speech dominance. In two patients with lateral precentral gyrus region gliomas and one patient with a left central sulcus AVM, the fMRI pattern incorrectly suggested primary corticobulbar motor dominance contralateral to the side of the lesion. In a patient with a right superior frontal gyrus AVM, fMRI revealed pronounced left dominant supplementary motor area activity in response to a bilateral complex motor task, but right superior frontal gyrus perilesional hemorrhage and edema subsequently caused left upper-extremity plegia. Pathophysiological factors that might have caused neurovascular uncoupling and facilitated pseudo-dominance at fMRI in these patients included direct tumor infiltration, neovascularity, cerebrovascular inflammation, and AVM-induced hemodynamic effects. Sixteen patients had proven (1 patient), probable (2 patients), or possible (13 patients) but unproven lesion-induced homotopic cortical reorganization.

CONCLUSION: Lesion-induced neurovascular uncoupling causing reduced fMRI signal in perilesional eloquent cortex, in conjunction with normal or increased activity in homologous brain regions, may simulate hemispheric dominance and lesion-induced homotopic cortical reorganization.

Author Information

Division of Neuroradiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin

Division of Neuroradiology, Departments of Radiology, Neurosurgery, and Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin

Division of Neuroradiology, Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin

Division of Neuroradiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin

Division of Neuroradiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin

Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin

Division of Neuroradiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin

Reprint requests: John L. Ulmer, M.D., Department of Radiology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226. Email: julmer@mcw.edu

Received, July 18, 2003

Accepted, April 7, 2004

Copyright © by the Congress of Neurological Surgeons