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Magnetic Resonance Imaging Measures of Posterior Cranial Fossa Morphology and Cerebrospinal Fluid Physiology in Chiari Malformation Type I

Alperin, Noam PhD*; Loftus, James R. BS*; Oliu, Carlos J. BS*; Bagci, Ahmet M. PhD*; Lee, Sang H. MS*; Ertl-Wagner, Birgit MD; Green, Barth MD§; Sekula, Raymond MD

Neurosurgery:
doi: 10.1227/NEU.0000000000000507
Research-Human-Clinical Studies: Editor's Choice
Editor's Choice
Abstract

BACKGROUND: It has been well documented that, along with tonsillar herniation, Chiari Malformation Type I (CMI) is associated with smaller posterior cranial fossa (PCF) and altered cerebrospinal fluid (CSF) flow and tissue motion in the craniocervical junction.

OBJECTIVE: This study assesses the relationship between PCF volumetry and CSF and tissue dynamics toward a combined imaging-based morphological-physiological characterization of CMI. Multivariate analysis is used to identify the subset of parameters that best discriminates CMI from a healthy cohort.

METHODS: Eleven length and volumetric measures of PCF, including crowdedness and 4th ventricle volume, 4 measures of CSF and cord motion in the craniocervical junction, and 5 global intracranial measures, including intracranial compliance and pressure, were measured by magnetic resonance imaging (MRI) in 36 symptomatic CMI subjects (28 female, 37 ± 11 years) and 37 control subjects (24 female, 36 ± 12 years). The CMI group was further divided based on symptomatology into “typical” and “atypical” subgroups.

RESULTS: Ten of the 20 morphologic and physiologic measures were significantly different between the CMI and the control cohorts. These parameters also had less variability and stronger significance in the typical CMI compared with the atypical. The measures with the most significance were clival and supraocciput lengths, PCF crowdedness, normalized PCF volume, 4th ventricle volume, maximal cord displacement (P < .001), and MR measure of intracranial pressure (P = .007). Multivariate testing identified cord displacement, PCF crowdedness, and normalized PCF as the strongest discriminator subset between CMI and controls. MR measure of intracranial pressure was higher in the typical CMI cohort compared with the atypical.

CONCLUSION: The identified 10 complementing morphological and physiological measures provide a more complete and symptomatology-relevant characterization of CMI than tonsillar herniation alone.

ABBREVIATIONS: CCJ, craniocervical junction

CMI, Chiari Malformation Type I

ICC, intracranial compliance

ICV, intracranial volume

MRICP, MR measure of intracranial pressure

PCF, posterior cranial fossa

PCFV, PCF volume

Author Information

*Department of Radiology, University of Miami, Miami, Florida;

Department of Radiology, University of Munich, Munich, Germany;

§Department of Neurological Surgery, University of Miami, Miami, Florida; and

Neurological Surgery, University of Pittsburgh, Pennsylvania

Correspondence: Noam Alperin, PhD, Department of Radiology, University of Miami, Professional Arts Center, Suite 713, 1150 NW 14th St, Miami, FL 33136. E-mail: NAlperin@med.miami.edu

Received April 01, 2014

Accepted July 01, 2014

Copyright © by the Congress of Neurological Surgeons