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Management of Atypical Cranial Meningiomas, Part 2: Predictors of Progression and the Role of Adjuvant Radiation After Subtotal Resection

Sun, Sam Q. BS*; Cai, Chunyu MD, PhD; Murphy, Rory K.J. MD§; DeWees, Todd PhD; Dacey, Ralph G. MD§; Grubb, Robert L. MD§; Rich, Keith M. MD§; Zipfel, Gregory J. MD§; Dowling, Joshua L. MD§; Leuthardt, Eric C. MD§; Leonard, Jeffrey R. MD§; Evans, John RN§; Simpson, Joseph R. MD, PhD; Robinson, Clifford G. MD; Perrin, Richard J. MD, PhD; Huang, Jiayi MD; Chicoine, Michael R. MD; Kim, Albert H. MD, PhD§

Neurosurgery:
doi: 10.1227/NEU.0000000000000462
Research-Human-Clinical Studies: Editor's Choice
Editor's Choice
Abstract

BACKGROUND: The efficacies of adjuvant stereotactic radiosurgery (SRS) and external beam radiation therapy (EBRT) for atypical meningiomas (AMs) after subtotal resection (STR) remain unclear.

OBJECTIVE: To analyze the clinical, histopathological, and radiographic features associated with progression in AM patients after STR.

METHODS: Fifty-nine primary AMs after STR were examined for predictors of progression, including the impact of SRS and EBRT, in a retrospective cohort study.

RESULTS: Twenty-seven patients (46%) progressed after STR (median, 30 months). On univariate analysis, spontaneous necrosis positively (hazard ratio = 5.2; P = .006) and adjuvant radiation negatively (hazard ratio = 0.3; P = .009) correlated with progression; on multivariate analysis, only adjuvant radiation remained independently significant (hazard ratio = 0.3; P = .006). SRS and EBRT were associated with greater local control (LC; P = .02) and progression-free survival (P = .007). The 2-, 5-, and 10-year actuarial LC rates after STR vs STR/EBRT were 60%, 34%, and 34% vs 96%, 65%, and 45%. The 2-, 5-, and 10-year actuarial progression-free survival rates after STR vs STR/EBRT were 60%, 30%, and 26% vs 96%, 65%, and 45%. Compared with STR alone, adjuvant radiation therapy significantly improved LC in AMs that lack spontaneous necrosis (P = .003) but did not improve LC in AMs with spontaneous necrosis (P = .6).

CONCLUSION: Adjuvant SRS or EBRT improved LC of AMs after STR but only for tumors without spontaneous necrosis. Spontaneous necrosis may aid in decisions to administer adjuvant SRS or EBRT after STR of AMs.

ABBREVIATIONS: AM, atypical meningioma

EBRT, external beam radiation therapy

GTR, gross total resection

LC, local control

NTR, near-total resection

PFS, progression-free survival

RT, radiation therapy

SRS, stereotactic radiosurgery

STR, subtotal resection

Author Information

*Washington University School of Medicine, St. Louis, Missouri

Departments of Pathology and Immunology,

§Neurosurgery, and

Radiation Oncology, Washington University, St. Louis, Missouri

Correspondence: Albert H. Kim, MD, PhD, Assistant Professor of Neurological Surgery, Washington University School of Medicine, CB 8057, 660 S Euclid Ave, St. Louis, MO 63110. E-mail: kima@wudosis.wustl.edu

Received December 27, 2013

Accepted May 24, 2014

Copyright © by the Congress of Neurological Surgeons