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Neurosurgery:
doi: 10.1227/NEU.0000000000000431
RESEARCH - HUMAN - CLINICAL STUDIES: PDF Only

Pipeline Embolization Device (PED) for the Treatment of Intra- and Extracranial Fusiform and Dissecting Aneurysms: Initial Experience and Long-term Follow-up.

Fischer, Sebastian M.D.; Perez, Marta Aguilar M.D.; Kurre, Wiebke M.D.; Albes, Guido M.D.; Bäzner, Hansjörg M.D.; Henkes, Hans M.D.

Published Ahead-of-Print
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Abstract

Background: Flow diverting stents offer a promising treatment option for complex aneurysms.

Objective: To evaluate the safety and efficacy of the Pipeline Embolization Device (PED) in the treatment of fusiform and dissecting aneurysms.

Methods: 65 consecutive patients with 69 fusiform and dissecting aneurysms underwent endovascular treatment using the PED. Target vessels included the ICA (n=28), MCA (n=2), ACA (n=1) VA (n=20), BA (n=17) and PCA (n=1). An average of 3.0 PEDs per target vessel was deployed.

Results: Exclusion of the aneurysm(s) immediately after PED deployment was not observed. Angiographic follow-up examinations were carried out in 63/65 patients (67/69 lesions). They showed complete cure of the target lesion in the first follow-up angiography (3.4 months mean interval) in 24 (36%) cases, partial elimination in 30 (45%), and no improvement in 13 (19%). After the latest follow-up (>1 DSA, n= 49, 27.4 months mean interval) complete cure of the target lesion was observed in 33 (67%), partial elimination in 14 (29%), and no change in 2 (4%). Taking all follow-up examinations together, 39/67 (58%) aneurysms were cured. The morbidity and mortality in the entire series were 5% and 8%, respectively.

Conclusion: Flow diverters offer a promising treatment option in fusiform and dissecting aneurysms. The introduction of flow-diverters with different densities might help to identify the optimal amount of coverage needed given different anatomical presentations of fusiform and dissecting aneurysms.

Copyright (C) by the Congress of Neurological Surgeons

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