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Hypnosis for Awake Surgery of Low-grade Gliomas: Description of the Method and Psychological Assessment

Zemmoura, Ilyess MD, PhD*,‡; Fournier, Eric MD§; El-Hage, Wissam MD, PhD‡,¶; Jolly, Virginie ST*; Destrieux, Christophe MD, PhD*,‡; Velut, Stéphane MD, PhD*,‡

doi: 10.1227/NEU.0000000000000993
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BACKGROUND: Awake craniotomy with intraoperative electric stimulation is a reliable method for extensive removal of low-grade gliomas while preserving the functional integrity of eloquent surrounding brain structures. Although fully awake procedures have been proposed, asleep-awake-asleep remains the standard technique. Anesthetic contraindications are the only limitation of this method, which is therefore not reliable for older patients with high-grade gliomas.

OBJECTIVE: To describe and assess a novel method for awake craniotomy based on hypnosis.

METHODS: We proposed a novel hypnosedation procedure to patients undergoing awake surgery for low-grade gliomas in our institution between May 2011 and April 2015. Surgical data were retrospectively recorded. The subjective experience of hypnosis was assessed by 3 standardized questionnaires: the Cohen Perceived Stress Scale, the Posttraumatic Stress Disorder Checklist Scale, the Peritraumatic Dissociative Experience Questionnaire, and a fourth questionnaire designed specifically for this study.

RESULTS: Twenty-eight questionnaires were retrieved from 43 procedures performed on 37 patients. The Peritraumatic Dissociative Experience Questionnaire revealed a dissociation state in 17 cases. The Perceived Stress Scale was pathological in 8 patients. Two patients in this group stated that they would not accept a second hypnosedation procedure. The Posttraumatic Stress Disorder Checklist Scale revealed 1 case of posttraumatic stress disorder. Burr hole and bone flap procedures were the most frequently reported unpleasant events during opening (15 of 52 events).

CONCLUSION: The main findings of our study are the effectiveness of the technique, which in all cases allowed resection of the tumor up to functional boundaries, and the positive psychological impact of the technique in most of the patients.

ABBREVIATIONS: AAA, asleep-awake-asleep

HGG, high-grade glioma

LGG, low-grade glioma

PCLS, Posttraumatic Stress Disorder Checklist Scale

PDEQ, Peritraumatic Dissociative Experience Questionnaire

PSS, Cohen Perceived Stress Scale

PTSD, posttraumatic stress disorder

*Service de Neurochirurgie,

§Service d'anesthésie-réanimation 1, and

Clinique Psychiatrique Universitaire, Centre Expert Dépression Résistante, Fondation FondaMental, CHRU de Tours, Tours, France;

Université François-Rabelais de Tours, Inserm U930 Imagerie et cerveau, Tours, France

Correspondence: Ilyess Zemmoura, MD, PhD, Service de Neurochirurgie, CHRU Bretonneau, 2 Boulevard Tonnellé, 37044 Tours Cedex, France. E-mail: ilyess.zemmoura@univ-tours.fr

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.neurosurgery-online.com).

Received March 10, 2015

Accepted July 20, 2015

Copyright © by the Congress of Neurological Surgeons