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The Dentate Nucleus and Its Projection System in the Human Cerebellum: The Dentate Nucleus Microsurgical Anatomical Study

Akakin, Akin MD*; Peris-Celda, Maria MD, PhD*,‡; Kilic, Turker MD, PhD§; Seker, Askin MD*; Gutierrez-Martin, Antonio MD, PhD; Rhoton, Albert Jr MD*

doi: 10.1227/NEU.0000000000000293
Research-Laboratory

BACKGROUND: Neurosurgical management of cerebellar lesions remains challenging. Thus, it is important to have sound knowledge of the microsurgical anatomy of the cerebellum and dentate nucleus (DN) and to define different types of exposure in a variety of surgical interventions.

OBJECTIVE: To examine the anatomy of the DN from a neurosurgical viewpoint using fiber tracking techniques.

METHODS: Ten formalin-fixed human hemispheres were dissected with the Ludwig and Klingler fiber dissection technique under × 6 to × 40 magnification. Anatomic images were created with 3-dimensional diffusion tensor imaging. The relationships of the DN to tentorium and suboccipital and lateral surfaces of the cerebellum and its spatial positioning relative to different surgical approaches in the cerebellum and fourth ventricle were examined. The fiber tracts terminating at and surrounding the DN were defined.

RESULTS: The DN is at greater risk of being injured in the transvermian and supratonsillar approaches to the cerebellum and fourth ventricle, with lesser risk in the telovelar and subtonsillar approaches. Superior approaches are safer compared with other approaches.

CONCLUSION: The DN represents an important anatomic structure in surgical interventions involving the posterior fossa, particularly in the elderly because of the common occurrence of atrophy-related problems in this age group. Functionally and anatomically, the DN is closely related to the superior and middle cerebellar peduncles. The inferior cerebellar peduncle poses positional risks because it follows an anterior and superior course relative to the DN. The telovelar approach is a safer procedure for interventions involving the pathological lesions of the fourth ventricle floor.

ABBREVIATIONS: DN, dentate nucleus

DTI, diffusion tensor imaging

*University of Florida, College of Medicine, Department of Neurosurgery, Neuroanatomy Laboratory, Gainesville, Florida;

La Fe University Hospital, Department of Neurosurgery, Valencia, Spain;

§Bahcesehir University, College of Medicine, Department of Neurosurgery, Istanbul, Turkey

Correspondence: Akin Akakin, MD, Bahcesehir University Medicine Faculty, Neurosurgery Department, Çýraðan Caddesi Osmanpaþa Mektebi Sokak No, 4-6, 34353 Beşiktaş, Istanbul, Turkey. E-mail: drakinakakin@yahoo.com

Received April 23, 2013

Accepted January 03, 2014

Copyright © by the Congress of Neurological Surgeons