BACKGROUND: Corpus callosotomy (CC) is a valuable palliative surgical option for children with medically refractory epilepsy due to generalized or multifocal cortical seizure onset.
OBJECTIVE: To investigate the extent of CC resulting in optimal seizure control in a pediatric patient population and to evaluate the modification of seizure profile after various CC approaches.
METHODS: The records of 58 children (3-22 years of age at the time of surgery) with medically refractory epilepsy who underwent CC between 1995 and 2011 were retrospectively reviewed.
RESULTS: Anterior two thirds callosotomy resulted in resolution of absence (P = .03) and astatic (P = .03) seizures, whereas anterior two thirds callosotomy followed by second-stage completion resulted in resolution of generalized tonic-clonic (GTC) (P = .03), astatic (P = .005), and myoclonic (P = .03) seizures in addition to a trend toward resolution of absence seizures (P = .08). Single-stage upfront complete callosotomy resulted in resolution of absence (P = .002), astatic (P < .0001), myoclonic (P = .007), and complex partial (P = .008) seizures in addition to a trend toward resolution of GTC (P = .06). In comparing a composite of subjects who underwent anterior two thirds callosotomy alone or 2-stage complete callosotomy before the second stage to complete the callosotomy with subjects who underwent upfront complete CC, a more favorable outcome was found in those with the upfront complete CC (P = .02).
CONCLUSION: Single-stage upfront complete callosotomy is effective in relieving a broader spectrum of seizure types than anterior two thirds callosotomy or 2-stage complete callosotomy in children. The advantages of single-stage complete callosotomy must be weighed against the potentially higher risk of neurological and operative complications.
ABBREVIATIONS: CC, corpus callosotomy
CPS, complex partial seizure
GTC, generalized tonic-clonic
SPS, simple partial seizure
VNS, vagal nerve stimulation
*Neural Engineering Laboratory, Mayo Clinic, Rochester, Minnesota;
Departments of ‡Neurological Surgery, and
§Neurology, St. Louis Children's Hospital, Washington University in St. Louis, St. Louis, Missouri;
¶Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, Missouri
Correspondence: Aimen S. Kasasbeh, MD, PhD, Neural Engineering Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55902. E-mail: firstname.lastname@example.org
Received April 04, 2013
Accepted September 25, 2013