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The Clinical Effects of Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus in Movement Disorders May Not Be Related to the Anatomical Target, Leads Location, and Setup of Electrical Stimulation

Mazzone, Paolo MD*; Sposato, Stefano MD; Insola, Angelo MD§; Scarnati, Eugenio PhD

Neurosurgery:
doi: 10.1227/NEU.0000000000000108
Concepts, Innovations and Techniques
Abstract

BACKGROUND: The pedunculopontine tegmental nucleus (PPTg) is a novel target for deep brain stimulation (DBS) in movement disorders.

OBJECTIVE: To clarify the relationships between the individual anatomic variations of the brainstem, the site in which the PPTg DBS is applied, and the clinical outcome in a relatively large number of patients affected by Parkinson disease or progressive supranuclear palsy.

METHODS: Magnetic resonance images have been used to evaluate brainstem anatomy and the relationships between lead position and specific brainstem landmarks. All data were matched on atlas representations of the PPTg and were correlated with Unified Parkinson Disease Rating Scale III (UPDRS III), subitems 27 to 30 of UPDRS III and the Hoehn and Yahr evaluations.

RESULTS: A high variance of brainstem parameters was evident, affecting the relationships between the position of the nucleus and lead contacts. According to the contacts giving the best clinical outcome, patients could be distinguished between those who required the use of 2 adjacent contacts and those who required stimulation through 2 nonadjacent contacts. Furthermore, in the former group the target coordinates were more lateral and deeper compared with the latter group.

CONCLUSION: Individual PPTg-DBS planning is required to overcome the inconsistencies linked to the high variability in the brainstem anatomy of patients. The lack of correlations between lead position, contact setup, and clinical outcome indicate that the benefits of PPTg DBS may not be strictly linked to the site of stimulation within the PPTg area, and may not depend upon the neurons still surviving in this region in Parkinson disease or progressive supranuclear palsy.

ABBREVIATIONS: DBS, deep brain stimulation

HY, Hoehn and Yahr

ML, medial lemniscus

PD, Parkinson disease

PH, Paxinos and Huang

PMJ, pontomesencephalic junction

PPTg, pedunculopontine tegmental nucleus

PSP, progressive supranuclear palsy

STN, subthalamic nucleus

UPDRS III, Unified Parkinson Disease Rating Scale III

VFL, ventricular floor line

FFL, fastigial floor line

Author Information

*Stereotactic and Functional Neurosurgery, CTO Hospital, ASL RMC, Rome, Italy

Neuroradiology, CTO Hospital, ASL RMC, Rome, Italy

§Neurophysiopathology, CTO Hospital, ASL RMC, Rome, Italy

Department of Applied Clinical and Biotechnological Sciences, University of L’Aquila, L’Aquila, Italy

Correspondence: Paolo Mazzone, MD, Operative Unit for Stereotactic and Functional Neurosurgery, ASL RMC, CTO Hospital, Via San Nemesio 21, 00145 Rome, Italy. E-mail: stereomaz@libero.it

Received February 09, 2013

Accepted July 11, 2013

Copyright © by the Congress of Neurological Surgeons