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The A1-A2 Diameter Ratio May Influence Formation and Rupture Potential of Anterior Communicating Artery Aneurysms

Flores, Bruno C. MD*; Scott, William W. MD*; Eddleman, Christopher S. MD, PhD*,‡; Batjer, H. Hunt MD*; Rickert, Kim L. MD*,‡

Neurosurgery:
doi: 10.1227/NEU.0000000000000125
Research-Human-Clinical Studies
Abstract

BACKGROUND: Specific morphological factors contribute to the hemodynamics of the anterior communicating artery (AComA). No study has examined the role of the A2 segment on AComA aneurysm presence and rupture.

OBJECTIVE: To examine the possibility that the ratio between A1 and A2 segments (A1-2 ratio) represents an independent risk factor for presence and rupture of AComA aneurysms (AComAAs).

METHODS: A retrospective review of an institutional aneurysm database was performed; patients with ruptured and unruptured AComAAs were identified. Two control groups were selected: group A (posterior circulation aneurysms) and group B (patients without intracranial aneurysms or other vascular malformations). Measurements of A1 and A2 diameters were obtained from digital subtraction angiography (64.1% of 3-D rotational digital subtraction angiography), and the A1-2 ratio calculated.

RESULTS: From January 2009 to April 2011, 156 patients were identified (52 AComAAs, 54 control group A, and 50 control group B). Mean age at the time of presentation was 56.09 years. Compared with both control groups, patients with AComAAs had greater A1 diameter (P < .01) and A1-2 ratio (P < .001) and smaller A2 diameter (P < .01). The A1-2 ratio correlated positively with the presence of AComAAs (P < .001). Ruptured AComAAs were smaller than unruptured ones (5.91 mm vs 9.25 mm, P = .02) and associated with a higher A1-2 Ratio (P = .02). The presence of a dominant A1 did not predict AComAA rupture (P = .15). The A1-2 ratio correlated positively with the presence of ruptured AComAAs (P = .04).

CONCLUSION: A1-2 ratio correlates positively with the presence and rupture of AComAAs and may facilitate treatment decision in cases of small, unruptured AComAAs.

ABBREVIATIONS: AComA, anterior communicating artery

AComAA, anterior communicating artery aneurysm

CTA, computerized tomography angiography

DSA, digital subtraction angiography

ISUIA, International Study of Unruptured Intracranial Aneurysms

MRA, magnetic resonance angiography

SAH, subarachnoid hemorrhage

STAR, Southwestern Tertiary Aneurysm Registry

Author Information

*Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas;

Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas

Correspondence: Bruno C. Flores, MD, Department of Neurological Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390. E-mail: bruno.flores@phhs.org

Received November 12, 2012

Accepted July 23, 2013

Copyright © by the Congress of Neurological Surgeons