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Transvenous Retrograde Nidus Sclerotherapy Under Controlled Hypotension (TRENSH): Hemodynamic Analysis and Concept Validation in a Pig Arteriovenous Malformation Model

Massoud, Tarik F. MD, PhD

Neurosurgery:
doi: 10.1227/01.neu.0000430765.80102.77
Research-Animal
Abstract

BACKGROUND: Transvenous retrograde nidus sclerotherapy under controlled hypotension (TRENSH) is a proposed novel concept for endovascular treatment of cerebral arteriovenous malformations (AVMs).

OBJECTIVE: To assess the experimental hemodynamic feasibility of TRENSH in a pig AVM model.

METHODS: We surgically constructed carotid-jugular fistula-type AVM models in 8 pigs. In 5 pigs (group 1) we hemodynamically assessed the AVM through the main arterial feeder (AF) and draining vein (DV) at systemic normotension (Systnorm). We then performed retrograde nidus angiography through the DV at progressively deeper levels of hemorrhagic systemic hypotension (Systhypo), and graded and correlated these angiograms with the degree of Systhypo. In another 3 pigs (group 2) we correlated the effects of temporary balloon occlusion of the main AF with the angiographic extent of retrograde nidus filling.

RESULTS: In group 1 pigs, the drop in AF pressure correlated strongly (r2 = 0.93-0.99) with the drop in DV pressure at progressively deeper Systhypo. Minimal retrograde nidus filling occurred at Systnorm. We observed progressively greater extents of retrograde nidus filling as the transnidal pressure gradients fell with deeper Systhypo. Near-complete retrograde permeation of the nidus was possible as the transnidal gradients approached 0 mm Hg. As more of the nidus filled, its concurrent emptying was documented through a greater number of DVs. Temporary AF occlusion resulted in improved retrograde nidus filling in all group 2 pigs.

CONCLUSION: Endovascular TRENSH appears feasible in a pig AVM model. Further experimental investigations of TRENSH are necessary to assess its full potential before future clinical applications.

ABBREVIATIONS: AF, arterial feeder

AVM, arteriovenous malformation

DV, draining vein

MAP, mean arterial feeder pressure

MVP, mean draining vein pressure

TBO, temporary balloon occlusion

TRENSH, transvenous retrograde nidus sclerotherapy under controlled hypotension

Author Information

Division of Interventional Neuroradiology, Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Radiology, Addenbrooke's Hospital and the University of Cambridge, Cambridge, United Kingdom

Correspondence: Tarik F. Massoud, MD, PhD, Section of Neuroradiology; Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine and Medical Center,The James H. Clark Center, E153, 318 Campus Dr, East Wing, First Floor, Stanford, CA 94305-5427. E-mail: tmassoud@stanford.edu

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Received October 29, 2012

Accepted April 23, 2013

Copyright © by the Congress of Neurological Surgeons