BACKGROUND: Esthesioneuroblastoma (ENB) is a rare malignant neuroendocrine tumor considered to be radiation sensitive. Local recurrence may be treated in a variety of ways, including stereotactic radiosurgery (SRS); however, little information on its effectiveness is available.
OBJECTIVE: To determine whether SRS is effective in providing local control for recurrent ENB.
METHODS: This was a retrospective single-institution experience including 109 patients with ENB treated at the Mayo Clinic (1962-2009). Sixty-three patients presented with Kadish stage C disease, and 21 patients developed local recurrence. Of these 21 patients, 7 patients underwent SRS at our institution and an additional patient underwent SRS after transnasal biopsy. Therefore, a total of 8 patients are reported.
RESULTS: The median age at time of local recurrence was 50 years. All patients had Kadish C disease at initial diagnosis. Six of 8 patients were found to have Hyams grade 3 disease; the remaining 2 patients had grade 2 disease. The median treatment volume was 8.4 cm3 (mean, 18.9 cm3; range, 1.4-76.3 cm3), and the median dose to the tumor margin was 15 Gy (mean, 14.4 ± 2.2 Gy; range, 10-18 Gy). Of the 16 treatments, 13 had adequate follow-up to assess treatment response, with 92% achieving local control over a median follow-up of 42 months from the time of SRS. Five lesions decreased in size, 7 lesions stabilized, and only 1 lesion had in-field progression. There were no documented complications secondary to SRS.
CONCLUSION: SRS appears to be a reasonable and safe option for treatment of intracranial recurrence of ENB.
ABBREVIATIONS: EBRT, external beam radiotherapy
SRS, stereotactic radiosurgery
Departments of *Neurosurgery
§Radiation Oncology, Mayo Clinic, Rochester, Minnesota
Correspondence: Jamie J. Van Gompel, MD, Department of Neurosurgery, Mayo Clinic, 200 First St, SW, Rochester, MN 55905. E-mail: email@example.com
Reprint Requests: Michael J. Link MD, Department of Neurosurgery, Mayo Clinic, 200 First St, SW, Rochester, MN 55905. E-mail: firstname.lastname@example.org
Received July 15, 2012
Accepted November 07, 2012