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Infection Risk in Neurointervention and Cerebral Angiography

Kelkar, Prashant S. DO; Fleming, J. Brett MD; Walters, Beverly C. MD, MSc; Harrigan, Mark R. MD

doi: 10.1227/NEU.0b013e31827d0ff7
Research-Human-Clinical Studies
Press Release

BACKGROUND: The risk of infection with cerebral angiography and neurointerventional procedures has not been defined. Likewise, although the use of routine prophylactic antibiotics has been advocated by some neurointerventionalists, the utility of prophylactic antibiotics in this setting has not been determined.

OBJECTIVE: To determine the rate of infection associated with neuroangiographic procedures in a clinical setting in which prophylactic antibiotics are not routinely given.

METHODS: All cerebral angiograms and neurointerventional procedures done by a single neurointerventionalist over a recent 7-year period were retrospectively reviewed. Patients with infections directly attributable to the procedure were identified. A sample size calculation was done to determine the necessary size of a randomized, controlled trial aimed at determining whether prophylactic antibiotics can lower the rate of infection.

RESULTS: Among a total of 2918 cerebral angiograms and neurointerventional procedures done without prophylactic antibiotics, there were 3 infections (0.1%) attributable to the procedure. All infections were localized femoral artery infections with no systemic complications. One infection occurred in a patient who was immunosuppressed because of treatment for cancer. Two of the patients required surgical debridement; all were treated with intravenous antibiotics with resolution of all infections. There were no central nervous system infections and no deaths associated with the infections.

CONCLUSION: These data suggest that the overall risk of infection associated with most neuroangiographic procedures is very low. Prophylactic antibiotic use may be a reasonable option for selected patients but is probably unnecessary for standard use in the context of meticulous care during procedures.

Department of Surgery, Division of Neurosurgery, University of Alabama, Birmingham, Alabama

Correspondence: Mark R. Harrigan, MD, Department of Surgery, Division of Neurosurgery, 1530 3rd Ave S, Birmingham, AL 35294-3410. E-mail:

Received May 26, 2012

Accepted October 23, 2012

Copyright © by the Congress of Neurological Surgeons