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Seizure Predictors and Control After Microsurgical Resection of Supratentorial Arteriovenous Malformations in 440 Patients

Englot, Dario J. MD, PhD*,‡; Young, William L. MD§,‡; Han, Seunggu J. MD*,‡; McCulloch, Charles E. PhD; Chang, Edward F. MD*,‡; Lawton, Michael T. MD*,‡

Neurosurgery:
doi: 10.1227/NEU.0b013e31825ea3ba
Research-Human-Clinical Studies
Abstract

BACKGROUND: Seizures are a common symptom of supratentorial arteriovenous malformations (AVMs), and uncontrolled epilepsy can considerably reduce patient quality of life. Potential risk factors for epilepsy in patients with AVMs are poorly understood, and the importance of achieving freedom from seizures in their surgical treatment remains underappreciated.

OBJECTIVE: To characterize risks factors for preoperative seizures and factors associated with postoperative freedom from seizures in patients with surgically resected supratentorial AVMs.

METHODS: We analyzed prospectively collected patient data for 440 patients who underwent microsurgical resection of supratentorial AVMs at our institution.

RESULTS: Among 440 patients with supratentorial AVMs, 130 (30%) experienced preoperative seizures, and 23 (18%) with seizures progressed to medically refractory epilepsy. Seizures were associated with a history of AVM hemorrhage (relative risk, 6.65; 95% confidence interval [CI], 3.81-11.6), male sex (relative risk, 2.07; 95% CI, 1.26-3.39), and frontotemporal lesion location (relative risk, 1.75; 95% CI, 1.05-2.93). After resection, 96% of patients had a modified Engel class I outcome, characterized by freedom from seizures (80%) or only 1 postoperative seizure (16%; mean follow-up, 20.7 ± 2.3 months). Comparable rates of postoperative seizures were seen in patients with (7%) or without (3%) preoperative seizures. AVMs with deep artery perforators were significantly associated with postoperative seizures (hazard ratio, 4.35; 95% CI, 1.61-11.7).

CONCLUSION: In the microsurgical treatment of supratentorial AVMs, hemorrhage, male sex, and frontotemporal location are associated with higher rates of preoperative seizures, whereas deep artery perforators are associated with postoperative seizures. Achieving freedom from seizure is an important goal that can be achieved in the surgical treatment of AVMs because epilepsy can significantly diminish patient quality of life.

ABBREVIATIONS: AED, antiepileptic drug

AVM, arteriovenous malformation

CI, confidence interval

mRS, modified Rankin Scale

RR, relative risk

UCSF, University of California, San Francisco

Author Information

*Department of Neurological Surgery

UCSF Center for Cerebrovascular Research

§Department of Anesthesia and Perioperative Care

Department of Epidemiology and Biostatistics, University of California, San Francisco, California

Correspondence: Dario J. Englot, MD, PhD, Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, Room M779, San Francisco, CA 94143-0112. E-mail: englot@gmail.com or englotdj@neurosurg.ucsf.edu

Reprint requests: Michael T. Lawton, MD, 505 Parnassus Ave, Box 0112, San Francisco, CA 94143-0112. E-mail: LawtonM@neurosurg.ucsf.edu

Received June 2, 2011

Accepted April 25, 2012

Copyright © by the Congress of Neurological Surgeons