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Intraoperative Visualization of Fiber Tracking Based Reconstruction of Language Pathways in Glioma Surgery

Kuhnt, Daniela MD*; Bauer, Miriam H. A. MSc*; Becker, Andreas MD*; Merhof, Dorit PhD§; Zolal, Amir MD; Richter, Mirco MSc§; Grummich, Peter PhD; Ganslandt, Oliver MD, PhD; Buchfelder, Michael MD, PhD; Nimsky, Christopher MD, PhD*

doi: 10.1227/NEU.0b013e318237a807
Research-Human-Clinical Studies

BACKGROUND: For neuroepithelial tumors, the surgical goal is maximum resection with preservation of neurological function. This is contributed to by intraoperative magnetic resonance imaging (iMRI) combined with multimodal navigation.

OBJECTIVE: We evaluated the contribution of diffusion tensor imaging (DTI)-based fiber tracking of language pathways with 2 different algorithms (tensor deflection, connectivity analysis [CA]) integrated in the navigation on the surgical outcome.

METHODS: We evaluated 32 patients with neuroepithelial tumors who underwent surgery with DTI-based fiber tracking of language pathways integrated in neuronavigation. The tensor deflection algorithm was routinely used and its results intraoperatively displayed in all cases. The CA algorithm was furthermore evaluated in 23 cases. Volumetric assessment was performed in pre- and intraoperative MR images. To evaluate the benefit of fiber tractography, language deficits were evaluated pre- and postoperatively and compared with the volumetric analysis.

RESULTS: Final gross-total resection was performed in 40.6% of patients. Absolute tumor volume was reduced from 55.33 ± 63.77 cm3 to 20.61 ± 21.67 cm3 in first iMRI resection control, to finally 11.56 ± 21.92 cm3 (P < .01). Fiber tracking of the 2 algorithms showed a deviation of the displayed 3D objects by <5 mm. In long-term follow-up only 1 patient (3.1%) had a persistent language deficit.

CONCLUSION: Intraoperative visualization of language-related cortical areas and the connecting pathways with DTI-based fiber tracking can be successfully performed and integrated in the navigation system. In a setting of intraoperative high-field MRI this contributes to maximum tumor resection with low postoperative morbidity.

*Department of Neurosurgery, University of Marburg, Marburg, Germany

Department of Neurosurgery, University of Erlangen-Nuremberg, Erlangen, Germany

§Visual Computing, University of Konstanz, Konstanz, Germany

Department of Neurosurgery, J.E. Purkinje University, Usti nad Labem, Czech Republic

Correspondence: Daniela Kuhnt, MD, Department of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany. E-mail: kuhntd@med.uni-marburg.de

Received March 6, 2011

Accepted August 31, 2011

Copyright © by the Congress of Neurological Surgeons