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Health-Related Quality of Life After Aneurysmal Subarachnoid Hemorrhage: Profile and Clinical Factors

Wong, George KC FRCSEd(SN)*; Poon, Wai S FRCS(Glasg), FRCSEd*; Boet, Ronald FCSSA‡; Chan, Matthew TV FANZCA§; Gin, Tony MD§; Ng, Stephanie CP PhD*; Zee, Benny CY PhD¶

doi: 10.1227/NEU.0b013e31820cd40d
Research-Human-Clinical Studies

BACKGROUND: Health-related quality of life has recently been suggested as a supplement to the traditional neurological outcome measures from the patient's perspective according to the World Health Organization model and may capture the effects of other factors such as posttraumatic stress disorder and neuroendocrine dysfunction.

OBJECTIVE: To explore the profile and clinical factors of quality of life after aneurysmal subarachnoid hemorrhage using the data we obtained from the recently completed Intravenous Magnesium Sulphate After Aneurysmal Subarachnoid Hemorrhage (IMASH) trial.

METHODS: This study was registered at and (NCT00124150). Data from a patient cohort obtained with the Short Form-36 questionnaire completed at 6 months were used for analysis.

RESULTS: Patients with aneurysmal subarachnoid hemorrhage demonstrated a decrease in quality of life according to the Short Form-36 at 6 months. The physical and mental health scores correlated with the Extended Glasgow Outcome Scale and had the potential to avoid the ceiling effect. Multiple regression analyses showed that the physical component scores were related to age, World Federation of Neurological Surgeons grade, and chronic hydrocephalus and that the mental component scores were not related to the traditional prognostic factors.

CONCLUSION: Subarachnoid hemorrhage caused a decrease in quality of life. Chronic hydrocephalus is related to a decrease in physical health quality of life.

*Division of Neurosurgery, §Department of Anesthesia and Intensive Care, and ¶School of Public Health, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; ‡Surgical Services, St George's Hospital, Christchurch, New Zealand

Received, May 27, 2010.

Accepted, October 21, 2010.

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Correspondence: George K.C. Wong, FRCSEd(SN)Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China. E-mail:

Copyright © by the Congress of Neurological Surgeons