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World Health Organization Grade II Gliomas and Subventricular Zone: Anatomic, Genetic, and Clinical Considerations

Vergani, Francesco MD; Martino, Juan MD; Gozé, Catherine PhD; Rigau, Valérie MD, PhD; Duffau, Hugues MD, PhD

Neurosurgery:
doi: 10.1227/NEU.0b013e31820b522a
Research-Human-Clinical Studies
Abstract

BACKGROUND: Recent studies suggest a possible origin of human gliomas from subventricular zone (SVZ) stem cells.

OBJECTIVE: To evaluate the relationship of World Health Organization grade II gliomas (GIIGs) with the SVZ and to investigate the presence of different genetic patterns, depending on their relationship with the SVZ.

METHODS: Forty-three consecutive patients were operated on for GIIG. Preoperative fluid-attenuated inversion recovery-weighted magnetic resonance images were reviewed to assess the presence of cortical involvement and the relationship between gliomas and the SVZ. Patients were divided into 2 groups: group 1, tumors in contact with the SVZ; and group 2, tumors not in contact with the SVZ. Preoperative and postoperative tumor volumes were calculated. Genetic analysis was performed to study 1p19q allelic loss.

RESULTS: Twenty-four patients were in group 1 and 19 in group 2. All tumors were in contact with the cortex. Preoperative volume was significantly larger in group 1 than in group 2 (P = .003). The proportion of total and subtotal resections was higher in group 2 (P = .01). Insular tumors never showed 1p19q codeletions. Noninsular tumors exhibited a significantly different incidence of complete 1p19q codeletion, with allelic loss more common in group 1 (P = .03).

CONCLUSION: GIIGs showed a constant relationship with the cortex and a larger volume when they came in contact with the ventricles. A distinct genetic pattern was found in noninsular SVZ GIIGs. This parameter can be considered for therapeutic management.

Author Information

*Department of Neurosurgery, The Newcastle Upon Tyne Hospitals, Newcastle, United Kingdom; ‡Department of Neurosurgery, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain; §Laboratoire de Biologie Cellulaire et Hormonale, Hôpital Arnaud de Villeneuve, Montpellier, France; ‖Team “Plasticity of Central Nervous System, Stem Cells and Glial Tumors,” INSERM U1051, Institute of Neurosciences of Montpellier, Hôpital Saint Eloi, Montpellier, France; Departments of ¶Neuropathology and #Neurosurgery, Hôpital Gui de Chauliac, Montpellier, France

Received, December 12, 2009.

Accepted, September 27, 2010.

Correspondence: Hugues Duffau, MD, PhD, Department of Neurosurgery, Hôpital Gui de Chauliac, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France. E-mail: h-duffau@chu-montpellier.fr

Copyright © by the Congress of Neurological Surgeons