Skip Navigation LinksHome > March 2011 - Volume 68 - Issue 3 > Comparative Effectiveness of Ventral vs Dorsal Surgery for C...
doi: 10.1227/NEU.0b013e31820777cf
Research-Human-Clinical Studies: Editor's Choice

Comparative Effectiveness of Ventral vs Dorsal Surgery for Cervical Spondylotic Myelopathy

Ghogawala, Zoher MD*†‡; Martin, Brook PhD, MPH∥; Benzel, Edward C MD¶; Dziura, James PhD§; Magge, Subu N MD#; Abbed, Khalid M MD†‡; Bisson, Erica F MD**; Shahid, Javed MD††; Coumans, Jean-Valery C E MD‡‡; Choudhri, Tanvir F MD§§; Steinmetz, Michael P MD¶; Krishnaney, Ajit A MD¶; King, Joseph T Jr MD, MSCE∥∥; Butler, William E MD‡‡; Barker, Fred G II MD‡‡; Heary, Robert F MD¶¶

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BACKGROUND: Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction.

OBJECTIVE: To determine the feasibility of a randomized clinical trial comparing the clinical effectiveness and costs of ventral vs dorsal decompression with fusion surgery for treating CSM.

METHODS: A nonrandomized, prospective, clinical pilot trial was conducted. Patients ages 40 to 85 years with degenerative CSM were enrolled at 7 sites over 2 years (2007-2009). Outcome assessments were obtained preoperatively and at 3 months, 6 months, and 1 year postoperatively. A hospital-based economic analysis used costs derived from hospital charges and Medicare cost-to-charge ratios.

RESULTS: The pilot study enrolled 50 patients. Twenty-eight were treated with ventral fusion surgery and 22 with dorsal fusion surgery. The average age was 61.6 years. Baseline demographics and health-related quality of life (HR-QOL) scores were comparable between groups; however, dorsal surgery patients had significantly more severe myelopathy (P < .01). Comprehensive 1-year follow-up was obtained in 46 of 50 patients (92%). Greater HR-QOL improvement (Short-Form 36 Physical Component Summary) was observed after ventral surgery (P = .05). The complication rate (16.6% overall) was comparable between groups. Significant improvement in the modified Japanese Orthopedic Association scale score was observed in both groups (P < .01). Dorsal fusion surgery had significantly greater mean hospital costs ($29 465 vs $19 245; P < .01) and longer average length of hospital stay (4.0 vs 2.6 days; P < .01) compared with ventral fusion surgery.

CONCLUSION: Surgery for treating CSM was followed by significant improvement in disease-specific symptoms and in HR-QOL. Greater improvement in HR-QOL was observed after ventral surgery. Dorsal fusion surgery was associated with longer length of hospital stay and higher hospital costs. The pilot study demonstrated feasibility for a larger randomized clinical trial.

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