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Is Preoperative Functional Magnetic Resonance Imaging Reliable for Language Areas Mapping in Brain Tumor Surgery? Review of Language Functional Magnetic Resonance Imaging and Direct Cortical Stimulation Correlation Studies

Giussani, Carlo MD; Roux, Frank-Emmanuel MD, PhD; Ojemann, Jeffrey MD; Sganzerla, Erik Pietro MD; Pirillo, David MD; Papagno, Costanza MD

Neurosurgery:
doi: 10.1227/01.NEU.0000360392.15450.C9
Literature Review
Abstract

OBJECTIVE: Language functional magnetic resonance imaging (fMRI) has been used extensively in the past decade for both clinical and research purposes. Its integration in the preoperative imaging assessment of brain lesions involving eloquent areas is progressively more diffused in neurosurgical practice. Nevertheless, the reliability of language fMRI is unclear. To understand the reliability of preoperative language fMRI in patients operated on for brain tumors, the surgical studies that compared language fMRI with direct cortical stimulation (DCS) were reviewed.

METHODS: Articles comparing language fMRI with DCS of language areas were reviewed with attention to the lesion pathology, the magnetic field, the language tasks used pre- and intraoperatively, and the validation modalities adopted to establish the reliability of language fMRI. We tried to explore the effectiveness of language fMRI in gliomas.

RESULTS: Nine language brain mapping studies compared the findings of fMRI with those of DCS. The studies are not homogeneous for tumor types, magnetic fields, pre- and intraoperative language tasks, intraoperative matching criteria, and results. Sensitivity and specificity were calculated in 5 studies (respectively ranging from 59% to 100% and from 0% to 97%).

CONCLUSION: The contradictory results of these studies do not allow consideration of language fMRI as an alternative tool to DCS in brain lesions located in language areas, especially in gliomas because of the pattern of growth of these tumors. However, language fMRI conducted with high magnet fields is a promising brain mapping tool that must be validated by DCS in methodological robust studies.

Author Information

Clinica Neurochirurgica, Dip. di Neuroscienze e Tecnologie Biomediche, Università degli Studi di Milano-Bicocca, Ospedale San Gerardo dei Tintori, Monza, Italy (Giussani) (Sganzerla) (Pirillo)

Institut National de la Santé et de la Recherche Médicale, Unité 825, Hôpital Purpan, Toulouse, France (Giussani) (Roux)

Department of Neurological Surgery, Children's Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle, Washington (Ojemann)

Neuropsicologia del Linguaggio, Dipartimento di Psicologia, Università degli Studi di Milano-Bicocca, Milan, Italy (Papagno)

Reprint requests: Carlo Giussani, MD, Clinica Neurochirurgica, Dip. di Neuroscienze e Tecnologie Biomediche, Università degli Studi di Milano-Bicocca, Ospedale San Gerardo dei Tintori, via Pergolesi 33, Monza, Italy. E-mail: carlo.giussani@libero.it

Received, January 3, 2009.

Accepted, July 23, 2009.

Copyright © by the Congress of Neurological Surgeons