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Skip Navigation LinksHome > October 2009 - Volume 65 - Issue 4 > A Tribute to Dr. David Kline: A New Approach to An Old Perip...
doi: 10.1227/01.NEU.0000335655.66073.27
Chapter 8

A Tribute to Dr. David Kline: A New Approach to An Old Peripheral Nerve Problem—Splicing Instead of Regenerating Disrupted Axons

Chang, Wesley Ph.D.; Sretevan, David M.D., Ph.D; Kliot, Michel M.D.

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OBJECTIVE: Our goal is to develop a novel method to repair damaged axons. This method relies on acutely restoring axonal continuity rather than the traditional approach of promoting axonal regeneration.

METHODS: Micro- and nanoechnological methods, in combination with focal application of electrical fields, are applied to individual and groups of axons both in vitro and in vivo.

RESULTS: Application of these techniques has permitted micromanipulation of axons at the cellular level and fusion of axonal membranes.

CONCLUSION: Although a great deal more work is necessary, our findings suggest that it may one day be possible to repair acutely disrupted axons by splicing their membranes back together.

Copyright © by the Congress of Neurological Surgeons


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