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Toward the Emergence of Nanoneurosurgery: Part IProgress in Nanoscience, Nanotechnology, and the Comprehension of Events in the Mesoscale Realm

Leary, Scott P. M.D.; Liu, Charles Y. M.D., Ph.D.; Yu, Cheng Ph.D.; Apuzzo, Michael L.J. M.D.

Neurosurgery:
doi: 10.1227/01.neu.0000181533.17956.f9
Topic Review: Special Article
Abstract

Since its original conception in 1959, the notion of nanotechnology and its potential ramifications have not only created fascination, but also intense scientific effort and scrutiny. Currently, research activities are being principally conducted in mesoscale, the realm between nanoscale and macroscale, with the rudiments of nanoscience being defined in realities and principles that will determine activities and discoveries in the future. This paper reviews and discusses the evolution of nanoscience, its contemporary status, and the discoveries that currently constitute the main components of the body of knowledge from a neurosurgical perspective. Specific attention is given to the developments in imaging, fabrication, nanostructures, nanoelectromechanical systems, molecular manufacturing, nanocomputation, and emerging physical and chemical concepts in mesoscale, as they will establish foundations for the realization of nanomedicine and nanoneurosurgery.

Author Information

Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California (Leary)

Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California (Liu)

Department of Radiation Oncology,Keck School of Medicine, University of Southern California, Los Angeles, California (Yu)

Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California (Apuzzo)

Reprint Requests: Michael L.J. Apuzzo 1420 San Pablo Street PMB A-106 Los Angeles, CA 90033 Email: neurosurgery-journal@hsc.usc.edu

Received, May 1, 2005.

Accepted, August 3, 2005

Copyright © by the Congress of Neurological Surgeons