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Functional Magnetic Resonance Imaging-integrated Neuronavigation: Correlation between Lesion-to-Motor Cortex Distance and Outcome

Krishnan, René M.D.; Raabe, Andreas M.D., Ph.D.; Hattingen, Elke M.D.; Szelényi, Andrea M.D.; Yahya, Hilal M.D.; Hermann, Elvis M.D.; Zimmermann, Michael M.D., Ph.D.; Seifert, Volker M.D., Ph.D.

Neurosurgery:
doi: 10.1227/01.NEU.0000137331.35014.5C
Technique and Application
Abstract

OBJECTIVE: The integration of functional magnetic resonance imaging (fMRI) data into neuronavigation is a new concept for surgery adjacent to the motor cortex. However, the clinical value remains to be defined. In this study, we investigated the correlation between the lesion-to-fMRI activation distance and the occurrence of a new postoperative deficit.

METHODS: fMRI-integrated “functional” neuronavigation was used for surgery around the motor strip in 54 patients. During standardized paradigms for hand, foot, and tongue movements, echo-planar imaging T2* blood oxygen level-dependent sequences were acquired and processed with BrainVoyager 2000 software (Brain Innovation, Maastricht, The Netherlands). Neuronavigation was performed with the VectorVision2 system (BrainLAB, Heimstetten, Germany). For outcome analysis, patient age, histological findings, size of lesion, distance to the fMRI areas, preoperative and postoperative Karnofsky index, postoperative motor deficit, and type of resection were analyzed.

RESULTS: In 45 patients, a gross total resection (>95%) was performed, and for 9 lesions (low-grade glioma, 4; glioblastoma, 5), a subtotal resection (80–95%) was achieved. The neurological outcome improved in 16 patients (29.6%), was unchanged in 29 patients (53.7%), and deteriorated in 9 patients (16.7%). Significant predictors of a new neurological deficit were a lesion-to-activation distance of less than 5 mm (P < 0.01) and incomplete resection (P < 0.05).

CONCLUSION: fMRI-integrated neuronavigation is a useful concept to assess the risk of a new motor deficit after surgery. Our data suggest that a lesion-to-activation distance of less than 5 mm is associated with a higher risk of neurological deterioration. Within a 10-mm range, cortical stimulation should be performed. For a lesion-to-activation distance of more than 10 mm, a complete resection can be achieved safely. The visualization of fiber tracks is desirable to complete the representation of the motor system.

Author Information

Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (Krishnan)

Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (Raabe)

Institute of Neuroradiology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (Hattingen)

Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (Szelényi)

Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (Yahya)

Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (Hermann)

Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (Zimmermann)

Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany (Seifert)

Reprint requests: René Krishnan, M.D., Department of Neurosurgery, Neurocenter, Johann Wolfgang Goethe University, Frankfurt am Main, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany. Email: R.Krishnan@em.uni-frankfurt.de

Received, August 15, 2003.

Accepted, April 26, 2004.

Copyright © by the Congress of Neurological Surgeons