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Drug Targeting into the Central Nervous System by Stereotactic Implantation of Biodegradable Microspheres

Menei, Philippe M.D.; Benoit, Jean-Pierre Ph.D.; Boisdron-Celle, Michelle Ph.D.; Fournier, Dominique M.D.; Mercier, Philippe M.D.; Guy, Gilles M.D.

Concepts and Innovations

CONTROLLED DRUG RELEASE in the central nervous system through an implantable polymeric vector has been developed in recent years. For this purpose, different polymeric devices composed primarily of synthetic biocompatible and biodegradable polymers have been investigated. The first polymeric devices developed were macroscopic implants (monolithic devices), which required open surgery for implantation. Microencapsulation methods, however, allow the production of microparticles or nanoparticles loaded with neuroactive drugs. Because of their size, these micro- or nanoparticles may be easily implanted by stereotaxy in discrete, precise, and functional areas of the brain without causing damage to the surrounding tissue. Presently, this method is most frequently applied in the fields of neuro-oncology and neurodegenerative diseases, but neurologically, the potential applications of drug targeting by stereotactic implantation of drug-loaded particles are legion.

Service de Neurochirurgie, Centre Hospitalo-Universitaire (PMen, DF, PMer, GG), and Laboratoire de Pharmacie Galénique et Biophysique Pharmaceutique, Faculté de Pharmacie (J-PB, MB-C), Université d'Angers, Angers, France

Reprint requests: P. Menei, Service de Neurochirurgie, CHU d'Angers, 4 rue Larrey, 49033 Angers Cedex 01, France.

Received, October 22, 1993. Accepted, December 20, 1993.

Copyright © by the Congress of Neurological Surgeons