Skip Navigation LinksHome > December 1990 - Volume 27 - Issue 6 > Pregnancy and the Risk of Hemorrhage from Cerebral Arteriove...
Neurosurgery:
Experimental and clinical studies: PDF Only

Pregnancy and the Risk of Hemorrhage from Cerebral Arteriovenous Malformations.

Horton, Jonathan C. M.D., Ph.D.; Chambers, Wiley A. M.D.; Lyons, Susan L. R.N.; Adams, Raymond D. M.D.; Kjellberg, Raymond N. M.D.

Collapse Box

Abstract

: We conducted a retrospective analysis of 451 women with an arteriovenous malformation (AVM) of the brain to determine whether pregnancy is a risk factor for cerebral hemorrhages. A total of 540 pregnancies occurred among our patient population, resulting in 438 live births and 102 abortions. There were 17 pregnancies complicated by a cerebral hemorrhage. The hemorrhage rate during pregnancy for women with an unruptured AVM was 0.035 +/-0.005 per person-year. The hemorrhage rate for nonpregnant women of childbearing age with an unruptured AVM was 0.031 +/- 0.002 per person-year. Pregnancy did not increase significantly the rate of first cerebral hemorrhage from an AVM (P = 0.35). We found that women with an AVM face a 3.5% risk of hemorrhage during pregnancy. Pregnancy is not a risk factor for hemorrhage in women without a previous hemorrhage. This conclusion assumes no selection bias exists in our study population; a bias would be introduced if the risk of fatal outcome after a hemorrhage were greater in pregnant women than in nonpregnant women. (Neurosurgery 27:867-872, 1990)

Copyright (C) by the Congress of Neurological Surgeons

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.