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Glioblastoma Multiforme Occurring 13 Years after Treatment of a Medulloblastoma.

Pearl, Gary S. M.D., Ph.D.; Mirra, Suzanne S. M.D.; Miles, Margaret L. B.S.
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: Although medulloblastoma is said to be capable of astrocytic differentiation, the development of an astrocytic neoplasm in association with a medulloblastoma is extremely rare. We report the light and electron microscopic features of a supratentorial glioblastoma that occurred 13 years after radiation therapy for a cerebellar medulloblastoma. The diverse ultrastructural features of the glioblastoma may reflect the multipotentiality of the cells in medulloblastoma. An alternate interpretation is that the glioblastoma represents a radiation-induced neoplasm after therapy for a medulloblastoma. (Neurosurgery, 6: 546-551, 1980)

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