The modulatory effect of estrogen on the neuronal activity in the barrel cortex of the rat. An electrophysiological studyKis, Zsolt; Budai, Dénes1; Imre, Gábor; Farkas, Tamás; Horváth, Szatmár; Toldi, JózsefCANeuroreport: 8 August 2001 - Volume 12 - Issue 11 - pp 2509-2512 Somatosensory Systems, Pain Abstract Author Information In acute experiments, the effects of iontophoretically applied 17β-estradiol hemisuccinate on the activity of the primary somatosensory cortical neurons were studied in ovariectomized rats by extracellular single-unit recording. 17β-Estradiol increased both the spontaneous and the vibrissa deflection- evoked responses, with an average latency of 24 min. It is suggested that this relatively long latency of the 17β-estradiol effect is based not so much on membrane mechanisms as on genomic mechanisms. Department of Comparative Physiology, University of Szeged, H-6701 Szeged, POB 533; 1Department of Biology, Juhász Gyula College, University of Szeged, Szeged, Hungary CACorresponding Author Received 19 April 2001; accepted 1 June 2001 © 2001 Lippincott Williams & Wilkins, Inc.