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Somatosensory Systems, Pain

The modulatory effect of estrogen on the neuronal activity in the barrel cortex of the rat. An electrophysiological study

Kis, Zsolt; Budai, Dénes1; Imre, Gábor; Farkas, Tamás; Horváth, Szatmár; Toldi, JózsefCA

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In acute experiments, the effects of iontophoretically applied 17β-estradiol hemisuccinate on the activity of the primary somatosensory cortical neurons were studied in ovariectomized rats by extracellular single-unit recording. 17β-Estradiol increased both the spontaneous and the vibrissa deflection- evoked responses, with an average latency of 24 min. It is suggested that this relatively long latency of the 17β-estradiol effect is based not so much on membrane mechanisms as on genomic mechanisms.

© 2001 Lippincott Williams & Wilkins, Inc.


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