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NeuroReport:
28 February 2000 - Volume 11 - Issue 3 - p 563-569
Computational Neuroscience

Interacting biological and electronic neurons generate realistic oscillatory rhythms

Szücs, Attila; Varona, Pablo; Volkovskii, Alexander R.; Abarbanel, Henry D. I.; Rabinovich, Mikhail I.; Selverston, Allen I.

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Abstract

Small assemblies of neurons such as central pattern generators (CPG) are known to express regular oscillatory firing patterns comprising bursts of action potentials. In contrast, individual CPG neurons isolated from the remainder of the network can generate irregular firing patterns. In our study of cooperative behavior in CPGs we developed an analog electronic neuron (EN) that reproduces firing patterns observed in lobster pyloric CPG neurons. Using a tuneable artificial synapse we connected the EN bidirectionally to neurons of this CPG. We found that the periodic bursting oscillation of this mixed assembly depends on the strength and sign of the electrical coupling. Working with identified, isolated pyloric CPG neurons whose network rhythms were impaired, the EN/biological network restored the characteristic CPG rhythm both when the EN oscillations are regular and when they are irregular.

© 2000 Lippincott Williams & Wilkins, Inc.

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