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Acute spinal cord injury diminishes silent synapses in the rat hippocampus

Jing, Yinglia,b,c,d,e; Bai, Fana,b,c,d,e; Chen, Huia,b,c,d,e; Dong, Haoa,b,c,d,e

doi: 10.1097/WNR.0000000000000885
Degeneration and Repair

Spinal cord injury (SCI) can promote profound functional modification in various brain centers. However, the question of whether SCI can affect the generation of silent synapses that regulate neuronal plasticity in the hippocampus remains unclear. In the present studies, we demonstrated that acute SCI diminished silent synapses in hippocampus of lesioned rats. Furthermore, the SCI induced decline in silent synapses appeared to require the activation of NR2B-containing N-methyl-D-aspartate receptors. Our data show that SCI impaired synaptic plasticity in the hippocampus, suggesting that this region may serve as a potential therapeutic target for meliorating impaired brain functions after SCI.

aRehabilitation Medicine of Capital Medical University

bChina Rehabilitation Research Center and Beijing Bo Ai Hospital

cInstitute of Rehabilitation Science of China

dCenter of Neural Injury and Repair, Beijing Institute for Brain Disorders

eBeijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China

Correspondence to Hao Dong, MD, Beijing Key Laboratory of Neural Injury and Rehabilitation, Number 10, Jiao Men North Road, Feng Tai District, Beijing 100068, China Tel: +86 108 756 967; fax: +86 106 757 1220; e-mail: tunghao1963@163.com

Received July 6, 2017

Accepted August 3, 2017

© 2017 Wolters Kluwer Health | Lippincott Williams & Wilkins