Skip Navigation LinksHome > July 11, 2012 - Volume 23 - Issue 10 > Oxygen-enhanced magnetic resonance imaging of the brain: a...
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Neuroreport:
doi: 10.1097/WNR.0b013e328353a4bb
Brain Imaging

Oxygen-enhanced magnetic resonance imaging of the brain: a rodent model

Wu, Yingweia,b*; Gao, Xinc*; Feng, Xiaoyuand; Tao, Xiaofenga,b; Tang, Cheuk Yinge

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Abstract

Oxygen-enhanced MRI has been shown to be a viable alternative to hyperpolarized gases for pulmonary imaging. The changes in the relaxation times due to hyperoxic conditions in the blood pool induced by inhalation of pure oxygen have produced sufficient signal changes for imaging applications. This is a safe and low-cost alternative for contrast-enhanced imaging. The application of oxygen-enhanced MRI in brain imaging has been much less studied. In this study, we investigated the changes in the relaxation times in the brain due to inhalation of pure oxygen in a rodent model. We also assessed the effects of reduced blood flow due to hyperoxic conditions. Despite the reduced blood flow, significant changes in T1, T2, and T2* relaxation times were detected. We conclude that oxygen-enhanced MRI can be used in rodent models of disease.

© 2012 Lippincott Williams & Wilkins, Inc.

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