Skip Navigation LinksHome > October 28, 2009 - Volume 20 - Issue 16 > Object memory in young and aged mice after sevoflurane anaes...
doi: 10.1097/WNR.0b013e328330cd2b
Behavioral, Integrative and Clinical Neuroscience

Object memory in young and aged mice after sevoflurane anaesthesia

Wiklund, Andreasa b; Granon, Sylviec; Faure, Philippec; Sundman, Evaa b; Changeux, Jean-Pierred; Eriksson, Lars I.a b

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Learning and memory are cognitive functions commonly impaired after surgery, especially in elderly patients. Our aim was to evaluate the effect of sevoflurane anaesthesia on episodic-like memory in young and aged wild-type mice and mice with altered nicotinic cholinergic neurotransmission (β2KO). Mice learned objects before randomization to control, anaesthesia or sham groups. Anaesthesia was maintained at 2.6% sevoflurane for 2 h, starting immediately after training. Object memory testing was performed after 24 h, when one familiar object was replaced by a nonfamiliar object. While nonanaesthetized mice showed memory retention of the familiar object, anaesthetized wild-type and β2KO mice showed impaired memory. Sevoflurane anaesthesia thus causes memory impairment in mice regardless of β2 receptor-mediated nicotinic cholinergic neurotransmission.

© 2009 Lippincott Williams & Wilkins, Inc.


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