Inverse amygdala and medial prefrontal cortex responses to surprised facesKim, Hackjin; Somerville, Leah H.; Johnstone, Tom; Alexander, Andrew L.; Whalen, Paul J.CANeuroreport: 19 December 2003 - Volume 14 - Issue 18 - pp 2317-2322 Brain Imaging Abstract Author Information Here we show inverse fMRI activation patterns in amygdala and medial prefrontal cortex (mPFC) depending upon whether subjects interpreted surprised facial expressions positively or negatively. More negative interpretations of surprised faces were associated with greater signal changes in the right ventral amygdala, while more positive interpretations were associated with greater signal changes in the ventral mPFC. Accordingly, signal change within these two areas was inversely correlated. Thus, individual differences in the judgment of surprised faces are related to a systematic inverse relationship between amygdala and mPFC activity, a circuitry that the animal literature suggests is critical to the assessment of stimuli that predict potential positive vs negative outcomes. W.M. Keck Laboratory for Functional Brain Imaging and Behavior, Departments of Psychiatry and Psychology, University of Wisconsin-Madison, 1500 Highland Ave., Waisman Ctr -T227, Madison, WI 53705, USA CACorresponding Author: firstname.lastname@example.org Received 2 September 2003; accepted 9 September 2003 © 2003 Lippincott Williams & Wilkins, Inc.