Skip Navigation LinksHome > December 19, 2003 - Volume 14 - Issue 18 > Aβ1-42 induces production of quinolinic acid by human macrop...
Neuroreport:
Ageing

Aβ1-42 induces production of quinolinic acid by human macrophages and microglia

Guillemin, Gilles J.1 CA; Smythe, George A.2; Veas, Laura A.1; Takikawa, Osamu3; Brew, Bruce J.1 4

Collapse Box

Abstract

We hypothesized that the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly the excitotoxin quinolinic acid (QUIN), may play an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we demonstrated that aggregated amyloid peptide Aβ1-42 induced indoleamine 2,3-dioxygenase (IDO) expression and resulted in a significant increase in production of QUIN by human primary macrophages and microglia. In contrast, Aβ1-40 and prion peptide (PrP) 106-126 did not induce any significant increase in QUIN production. These data imply that local QUIN production may be one of the factors involved in the pathogenesis of neuronal damage in AD.

© 2003 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.