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Clinical Neuroscience and Neuropathology: Clinical Neuroscience

Neurokinin-1 receptors are decreased in major depressive disorder

Stockmeier, Craig A.CA; Shi, Xiaochun; Konick, Lisa1; Overholser, James C.2; Jurjus, George1; Meltzer, Herbert Y.1; Friedman, Lee3; Blier, Pierre4; Rajkowska, Grazyna

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Treatment with an antagonist at the neurokinin-1 (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [125I]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n  = 12, six females) and psychiatrically normal subjects (n  = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p  = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.

© 2002 Lippincott Williams & Wilkins, Inc.


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