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Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats

Parker, Linda A.CA; Mechoulam, Raphael1; Schlievert, Coralynne

Motivation, Emotion, Feeding, Drinking

Rats display conditioned rejection reactions during an oral infusion of a flavor previously paired with an emetic drug; considerable evidence indicates that these rejection reactions reflect nausea. Here we report that cannabidiol, a major non-psychoactive cannabinoid found in marijuana and its synthetic dimethylheptyl homolog interfere with nausea elicited by lithium chloride and with conditioned nausea elicited by a flavor paired with lithium chloride. These results suggest that cannabinoids without psychoactive side-effects may have therapeutic value in the treatment of chemotherapy-induced nausea.

Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada

1Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University Medical Faculty, Jerusalem 91120, Israel

CACorresponding Author

Received 18 January 2002 accepted 22 January 2002

© 2002 Lippincott Williams & Wilkins, Inc.