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Impairment of mitogenic activation of peripheral blood lymphocytes in Alzheimer's disease

Stieler, Jens T.; Lederer, Carla; Brückner, Martina K.; Wolf, Henrike; Holzer, Max; Gertz, Hermann-Josef; Arendt, ThomasCA

Clinical Neuroscience and Neuropathology

Cell-cycle dysregulation might be critically involved in the process of neurodegeneration in Alzheimer's disease (AD). We now provide evidence for a dysfunction of the cell division cycle as a more general cellular phenomenon of the disease. Peripheral blood lymphocytes, stimulated with mitogenic compounds, were less able to express CD69, an early proliferation marker, in AD patients than in age-matched controls. Expression levels of CD69 of both T-cells and B-cells correlated inversely with the Mini-mental Scale. The results suggest that a systemic failure of cellular proliferation control might be of critical importance for the pathomechanism of AD.

Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, and Department of Psychiatry, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany

CACorresponding Author

Received 6 September 2001; accepted 15 October 2001

© 2001 Lippincott Williams & Wilkins, Inc.