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Neuroreport:
Clinical Neuroscience and Neuropathology

Impairment of mitogenic activation of peripheral blood lymphocytes in Alzheimer's disease

Stieler, Jens T.; Lederer, Carla; Brückner, Martina K.; Wolf, Henrike; Holzer, Max; Gertz, Hermann-Josef; Arendt, ThomasCA

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Abstract

Cell-cycle dysregulation might be critically involved in the process of neurodegeneration in Alzheimer's disease (AD). We now provide evidence for a dysfunction of the cell division cycle as a more general cellular phenomenon of the disease. Peripheral blood lymphocytes, stimulated with mitogenic compounds, were less able to express CD69, an early proliferation marker, in AD patients than in age-matched controls. Expression levels of CD69 of both T-cells and B-cells correlated inversely with the Mini-mental Scale. The results suggest that a systemic failure of cellular proliferation control might be of critical importance for the pathomechanism of AD.

© 2001 Lippincott Williams & Wilkins, Inc.

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