Axonal projection of olfactory sensory neurons during the developmental and regeneration processesSengoku, Shintaro1,*; Ishii, Tomohiro1; Serizawa, Shou1; Nakatani, Hiroko1; Nagawa, Fumikiyo1; Tsuboi, Akio1,2; Sakano, Hitoshi1, CANeuroreport: 17 April 2001 - Volume 12 - Issue 5 - pp 1061-1066 Developmental Neuroscience Abstract Author Information We have studied the projection of olfactory sensory neurons (OSNs), during the developmental and regeneration processes, using the transgenic mouse carrying the differently tagged odorant receptor genes, MOR28. We have found that the axon terminals of the two sets of MOR28-positive OSNs, one expressing the lacZ tag and the other expressing the green fluorescent protein gene, are dispersed and intermingled at early developmental or regeneration stages. Projection areas become more distinct and separated at later stages, however, two sets of axon fibers are not typically bundled or segregated during pathfinding. It appears that segregation of axons mainly occurs when they target at the olfactory bulb to form the glomerular structure. 1Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-0032; 2PRESTO, Japan Science and Technology Corporation, 9-6 Konya-imamachi, Kumamoto 860-0012, Japan *Present address: McKinsey & Co Inc. 1-9-9 Rappongi, Minato-ku, Tokyo 106-8509, Japan CACorresponding Author Received 22 December 2000; accepted 30 January 2001 © 2001 Lippincott Williams & Wilkins, Inc.