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Neuropharmacology and Neurotoxicology

Noradrenaline does not change the mode of discharge of auditory cortex neurons

Manunta, Yves1; Edeline, Jean-Marc1,2

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The mode of discharge of auditory cortex cells was studied during iontophoretic application of noradrenaline (NA). Only seven of 190 cells showed changes in interspike interval distribution during NA application. A similar conclusion was drawn when the analysis focused on 68 cells classified as burs+ing (n = 15), regular spiking (n = 49) or thin spike (n = 4) cells. Only two bursting cells showed changes in their ISI distribution. The effects on the mode of discharge were independent of the effect on the spike rate and were not a function of cortical depth. These results suggest that the changes in firing mode previously described in vitro occur for a limited percentage of cells and/or for cell types not very often recorded in vivo.

© 2000 Lippincott Williams & Wilkins, Inc.


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