Noradrenaline does not change the mode of discharge of auditory cortex neuronsManunta, Yves1; Edeline, Jean-Marc1,2Neuroreport: 17 January 2000 - Volume 11 - Issue 1 - p 23–26 Neuropharmacology and Neurotoxicology Abstract Author Information The mode of discharge of auditory cortex cells was studied during iontophoretic application of noradrenaline (NA). Only seven of 190 cells showed changes in interspike interval distribution during NA application. A similar conclusion was drawn when the analysis focused on 68 cells classified as burs+ing (n = 15), regular spiking (n = 49) or thin spike (n = 4) cells. Only two bursting cells showed changes in their ISI distribution. The effects on the mode of discharge were independent of the effect on the spike rate and were not a function of cortical depth. These results suggest that the changes in firing mode previously described in vitro occur for a limited percentage of cells and/or for cell types not very often recorded in vivo. 1Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication, CNRS UMR 8620, Université Paris-Sud, Bât 446, 91405 Orsay, France 2Corresponding Author: Jean-Marc Edeline Acknowledgements: We thank E. Hennevin, N. Cotillon and R. Metherate for helpful comments on this paper. Research supported by MRT grant 91CO956 and by EC grant (Human Capital and Mobility CHRXCT930269). Received 1 September 1999; accepted 20 October 1999 © 2000 Lippincott Williams & Wilkins, Inc.