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Neuropharmacology and Neurotoxicology

Effects of dizocilpine (MK 801) on noradrenaline, serotonin and dopamine release and uptake

Callado, Luis F.1; Hopwood, Sarah E.1; Hancock, Pamela J.1; Stamford, Jonathan A.1,2

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In the present study, we examined the actions of the NMDA antagonist dizocilpine (MK801) on electrically evoked release and uptake of noradrenaline (NA) in the locus coeruleus (LC), serotonin (5-HT) in the dorsal raphe nucleus (DRN) and dopamine (DA) in the nucleus accumbens (NAc), measured by fast cyclic voltammetry (FCV) in rat brain slices. Dizocilpine (10 μM) significantly increased NA (to 248 ± 15%) and 5-HT release (to 184 ± 29%) and slowed monoamine uptake in the LC (t1/2 = 853 ± 129%) and the DRN (t1/2 = 387 ± 70%), respectively. However, dizocilpine had no effect on DA release or uptake in NAc. Actions on monoamines are thus likely and should be considered in the interpretation of data regarding dizocilpine.

© 2000 Lippincott Williams & Wilkins, Inc.


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