NeuroReport

Skip Navigation LinksHome > November 26, 1999 - Volume 10 - Issue 17 > α‐Lipoic acid prevents 3,4‐methylenedioxy‐methamphetamine (M...
Neuroreport:
Neuropharmacology and Neurotoxicology

α‐Lipoic acid prevents 3,4‐methylenedioxy‐methamphetamine (MDMA)‐induced neurotoxicity

Aguirre, Norberto1; Barrionuevo, Meritxell1; Ramírez, María J.1; Río, Joaquín Del1; Lasheras, Berta1,2

Collapse Box

Abstract

A single administration of 3,4-methylenedioxymetham-phetamine (MDMA, 20 mg/kg, i.p.), induced significant hyperthermia in rats and reduced 5-hydroxytryptamine (5-HT) content and [3H]paroxetine-labeled 5-HT transporter density in the frontal cortex, striatum and hippocampus by 40–60% 1 week later. MDMA treatment also increased glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus. Repeated administration of the metabolic antioxidant α-lipoic acid (100 mg/kg, i.p., b.i.d. for 2 consecutive days) 30 min prior to MDMA did not prevent the acute hyperthermia induced by the drug; however, it fully prevented the serotonergic deficits and the changes in the glial response induced by MDMA. These results further support the hypothesis that free radical formation is responsible for MDMA-induced neurotoxicity.

© 1999 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.