Skip Navigation LinksHome > January 26, 1998 - Volume 9 - Issue 2 > Dopamine markers and general cognitive ability
Cognitive Neuroscience and Neuropsychology

Dopamine markers and general cognitive ability

Ball, David1,6; Hill, Linzy1; Eley, Thalia C.1; Chorney, Michael J.2; Chorney, Karen3; Thompson, Lee A.4; Detterman, Douglas K.3; Benbow, Camilla4; Lubinski, David4; Owen, Michael5; McGuffin, Peter5; Plomin, Robert1

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BECAUSE general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.

© Lippincott-Raven Publishers.


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