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Polyamines modulate the function of transfected glutamate receptor mGluR1a.

Manev, Radmila M.; Gabellini, Nadia; Manev, Hari

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Abstract

Metabotropic glutamate receptor mGluR1a was expressed in human embryonic kidney 293 cells. 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) stimulated dose-dependently, phosphoinositide (PI) hydrolysis in transfected, but not in non-transfected cells. The polyamine spermine did not affect PI hydrolysis in the absence of 1S,3R-ACPD even at a concentration of 1 mM, but it potentiated the stimulatory action of 1S,3R-ACPD at 10 [mu]M. The modulatory action of spermine was mimicked by spermidine but not by the short polyamine putrescine.

(C) Lippincott-Raven Publishers.

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