Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
Plotkin, Scott R. M.D., Ph.D
Scott R. Plotkin, M.D., Ph.D., is director of the Neurofibromatosis Clinic at the Massachusetts General Hospital Cancer Center in Boston, MA.
Q What is the latest on neurofibromatosis, which causes tumors to grow on nerves?
DR. SCOTT R. PLOTKIN
A There's a lot of new research being done on neurofibromatosis. Here are two areas that I think are interesting:
My research team and I are currently studying this technique, in which a person is scanned from head to toe in 45 minutes, and the stations are fused into a single image through sophisticated software. This technique has a number of potential advantages over traditional MRI scans. First, if patients have multiple tumors spread throughout their body, all the tumors can be imaged in a single MRI session. Second, these scans can help estimate a patient's overall response to treatment, even if their doctor is treating a specific tumor in their left arm.
Most neurofibromatosis-related tumors are benign, and their cells don't divide as rapidly as those in malignant (or cancerous) tumors. Instead of trying to kill dividing cells with traditional chemotherapy, we are using novel chemotherapy drugs that can suppress inappropriately activated signaling pathways that cause tumor growth. Researchers are interested in effective chemotherapy drugs since surgical removal of tumors is associated with risks. Another benefit is that chemotherapy treats the entire person rather than one specific tumor.
©2008 American Academy of Neurology
Friend's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Neurology Now.
Send a copy to your email
Your message has been successfully sent to your friend.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Speak Up Essays
Letters to the Editor
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics