Most living kidney donors met consistent glucose tolerance and blood pressure criteria over the course of five decades at three major US transplant centers, reported a study published online ahead of print by the American Journal of Transplantation.
The Renal and Lung Living Donors Evaluation (RELIVE) Study evaluated data on 8,951 living kidney donors who donated between 1963 and 2007 at Mayo Clinic, the University of Alabama at Birmingham, and the University of Minnesota.
“In this large cohort of kidney donors, we observed notable trends in donor characteristics over the last five decades: the number of living kidney donors at the three study centers increased steadily over time, there was a marked rise in the proportion of donors unrelated to their recipient, and a higher proportion of female donors,” wrote the authors, who were led by Sandra J. Taler, MD, of the Mayo Clinic.
“While the mean age at donation increased, donors [older than] 60 years constituted a stable minority of up to 4% over the period studied.”
The percentage of donors older than 40 increased from 38% to 51% during that time, and the proportion with obesity rose from 8% to 26%.
One percent to two percent of donors had a fasting blood glucose above 125 mg/dL, and most recorded blood pressure measurements were below 140/90 mmHg.
“While an increasing number of programs reported willingness to accept hypertensive donors, particularly older ones, practices among the three RELIVE study sites extended only to those with milder forms of hypertension,” the study authors wrote.
Accepted donors 60 years of age or older, though, were more likely to have obesity, glucose intolerance, or hypertension compared with younger donors.
For the entire living donor population, however, there were trends worthy of monitoring.
“We did see an increase in the maximal values for all reported parameters, highlighting the need for prospective data collection and long-term follow-up.”