Menopause

Skip Navigation LinksHome > July/August 2008 - Volume 15 - Issue 4 > Centrally located body fat is related to inflammatory marker...
Menopause:
doi: 10.1097/gme.0b013e318159f1a2
Articles

Centrally located body fat is related to inflammatory markers in healthy postmenopausal women

Perry, Courtney D. MS, RD1; Alekel, D. Lee PhD1; Ritland, Laura M. BS1; Bhupathiraju, Shilpa N. MS1; Stewart, Jeanne W. MS1; Hanson, Laura N. MS1; Matvienko, Oksana A. PhD2; Kohut, Marian L. PhD3; Reddy, Manju B. PhD1; Van Loan, Marta D. PhD4; Genschel, Ulrike PhD5

Collapse Box

Abstract

Objective: C-reactive protein and fibrinogen are established atherosclerotic cardiovascular disease risk factors. These acute-phase proteins and the proinflammatory cytokines tumor necrosis factor α, interleukin-6, and interleukin-1β may be elevated in obesity and with menopause. The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women.

Design: We used dual-energy x-ray absorptiometry to assess overall and regional body composition (fat mass in particular) in 242 postmenopausal women in relation to plasma fibrinogen, serum C-reactive protein, and these proinflammatory cytokines.

Results: Multiple regression analyses revealed that 36% of the variability in C-reactive protein (F = 32.4, P ≤ 0.0001) was accounted for by androidal fat mass (16.1%, P ≤ 0.0001), white blood cells (5.6%, P ≤ 0.0001), and age (2.3%, P = 0.0045). Regression analyses revealed that 30% of the variability in fibrinogen (F = 24.5, P ≤ 0.0001) was accounted for by white blood cells (3.1%, P = 0.0015), hip fat mass (2.2%, P = 0.0081), years since menopause (0.9%, P = 0.082), and geographic site (P ≤ 0.0001). Our results indicated that androidal fat mass and hip fat mass contributed to C-reactive protein and fibrinogen, respectively, whereas we found no association between whole-body or regional fat measures and cytokines.

Conclusion: Further study is warranted to determine the responsiveness of these acute-phase proteins and cytokines to loss of body fat through exercise and dietary intervention in postmenopausal women.

©2008The North American Menopause Society

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.