Skip Navigation LinksHome > July/August 2008 - Volume 15 - Issue 4 > Centrally located body fat is related to inflammatory marker...
doi: 10.1097/gme.0b013e318159f1a2

Centrally located body fat is related to inflammatory markers in healthy postmenopausal women

Perry, Courtney D. MS, RD1; Alekel, D. Lee PhD1; Ritland, Laura M. BS1; Bhupathiraju, Shilpa N. MS1; Stewart, Jeanne W. MS1; Hanson, Laura N. MS1; Matvienko, Oksana A. PhD2; Kohut, Marian L. PhD3; Reddy, Manju B. PhD1; Van Loan, Marta D. PhD4; Genschel, Ulrike PhD5

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Objective: C-reactive protein and fibrinogen are established atherosclerotic cardiovascular disease risk factors. These acute-phase proteins and the proinflammatory cytokines tumor necrosis factor α, interleukin-6, and interleukin-1β may be elevated in obesity and with menopause. The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women.

Design: We used dual-energy x-ray absorptiometry to assess overall and regional body composition (fat mass in particular) in 242 postmenopausal women in relation to plasma fibrinogen, serum C-reactive protein, and these proinflammatory cytokines.

Results: Multiple regression analyses revealed that 36% of the variability in C-reactive protein (F = 32.4, P ≤ 0.0001) was accounted for by androidal fat mass (16.1%, P ≤ 0.0001), white blood cells (5.6%, P ≤ 0.0001), and age (2.3%, P = 0.0045). Regression analyses revealed that 30% of the variability in fibrinogen (F = 24.5, P ≤ 0.0001) was accounted for by white blood cells (3.1%, P = 0.0015), hip fat mass (2.2%, P = 0.0081), years since menopause (0.9%, P = 0.082), and geographic site (P ≤ 0.0001). Our results indicated that androidal fat mass and hip fat mass contributed to C-reactive protein and fibrinogen, respectively, whereas we found no association between whole-body or regional fat measures and cytokines.

Conclusion: Further study is warranted to determine the responsiveness of these acute-phase proteins and cytokines to loss of body fat through exercise and dietary intervention in postmenopausal women.

©2008The North American Menopause Society


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