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Menopause:
doi: 10.1097/GME.0b013e31829e40b8
Original Articles

Efficacy of omega-3 for vasomotor symptoms treatment: a randomized controlled trial

Cohen, Lee S. MD1; Joffe, Hadine MD, MSc1; Guthrie, Katherine A. PhD2; Ensrud, Kristine E. MD3; Freeman, Marlene MD1; Carpenter, Janet S. PhD, RN, FAAN4; Learman, Lee A. MD, PhD5; Newton, Katherine M. PhD6; Reed, Susan D. MD, MPH7; Manson, JoAnn E. MD, DrPH8; Sternfeld, Barbara PhD9; Caan, Bette DrPH9; Freeman, Ellen W. PhD10; LaCroix, Andrea Z. PhD2; Tinker, Lesley F. PhD2; Booth-LaForce, Cathryn PhD11; Larson, Joseph C. MS2; Anderson, Garnet L. PhD2

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Abstract

Objective

This study aims to determine the efficacy and tolerability of omega-3 fatty acids in reducing vasomotor symptoms (VMS) frequency and bother in perimenopausal and postmenopausal women.

Methods

This study was a 12-week, three-by-two factorial, randomized controlled trial. Eligible women were randomized to a double-blind comparison of omega-3 (n = 177) or placebo (n = 178) capsules, and simultaneously to yoga (n = 107), aerobic exercise (n = 106), or their usual physical activity (n = 142). Participants received 1.8 g of omega-3 daily for 12 weeks. Each capsule contained ethyl eicosapentaenoic acid (425 mg), docosahexaenoic acid (100 mg), and other omega-3s (90 mg). Primary outcomes were VMS frequency and bother. Secondary outcomes included sleep quality (Pittsburgh Sleep Quality Index), insomnia symptoms (Insomnia Severity Index), depressive symptoms (Physician’s Health Questionnaire-8), and anxiety (Generalized Anxiety Disorder-7).

Results

The mean baseline frequency of VMS per day was 7.6 (95% CI, 7.0 to 8.2). After 12 weeks, the reduction in VMS frequency with omega-3 (−2.5; 95% CI, −3.0 to −1.9) did not differ significantly from that with placebo (−2.7; 95% CI, −3.3 to −2.2), with a relative difference of 0.3 fewer hot flashes per day (95% CI, −0.5 to 1.0; P = 0.28). Changes in VMS bother at 12 weeks were also similar between groups, with no relative difference on a four-point scale (95% CI, −0.1 to 0.2; P = 0.36). Omega-3s compared with placebo showed no improvement in self-reported sleep or mood (P > 0.09 for all comparisons).

Conclusions

Among healthy, sedentary perimenopausal and postmenopausal women, a 12-week treatment with omega-3 does not improve VMS frequency, VMS bother, sleep, or mood compared with placebo.

© 2013 by The North American Menopause Society

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