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Menopause and benign paroxysmal positional vertigo

Ogun, Oluwaseye Ayoola MD1; Büki, Bela MD, PhD2; Cohn, Edward S. MD1; Janky, Kristen L. AuD, PhD1; Lundberg, Yunxia Wang PhD1

doi: 10.1097/GME.0000000000000190
Brief Reports

Objective This study was designed to examine the age and sex distribution and the effects of menopause in a large cohort of participants diagnosed with benign paroxysmal positional vertigo (BPPV).

Methods We analyzed 1,377 BPPV patients and surveyed 935 women from this group—all diagnosed at the Boys Town National Research Hospital in the last decade.

Results A detailed age and sex distribution analysis of BPPV onset showed that aging had a profound impact on BPPV occurrence in both sexes, and that perimenopausal women were especially susceptible to BPPV (3.2:1 female-to-male ratio). The latter is a novel finding and was confirmed by a direct survey of female BPPV patients (168 participated). In addition, there was a pronounced female preponderance (6.8:1 female-to-male ratio) in BPPV in the teenage group despite its low prevalence in this age group.

Conclusions Data suggest that hormonal fluctuations (especially during menopause) may increase the tendency to develop BPPV.

From the 1Boys Town National Research Hospital, Omaha, NE; and 2Department of Otolaryngology, County Hospital, Krems, Austria.

Received September 11, 2013; revised and accepted November 14, 2013.

Funding/support: This work was supported by grants from the National Institutes of Health (R01DC008603, R01DC008603-S1, and P20GM103471 [formerly P20RR018788] pilot funding to Y.W.L., postdoctoral training grant T32DC000013 to O.A.O., and P20GM103471 pilot funding to E.S.C.) and by the Boys Town National Research Hospital.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Yunxia Wang Lundberg, PhD, Vestibular Genetics Laboratory, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131. E-mail: Yesha.Lundberg@boystown.org

© 2014 by The North American Menopause Society.