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Menopause and benign paroxysmal positional vertigo

Ogun, Oluwaseye Ayoola MD1; Büki, Bela MD, PhD2; Cohn, Edward S. MD1; Janky, Kristen L. AuD, PhD1; Lundberg, Yunxia Wang PhD1

doi: 10.1097/GME.0000000000000190
Brief Reports

Objective: This study was designed to examine the age and sex distribution and the effects of menopause in a large cohort of participants diagnosed with benign paroxysmal positional vertigo (BPPV).

Methods: We analyzed 1,377 BPPV patients and surveyed 935 women from this group—all diagnosed at the Boys Town National Research Hospital in the last decade.

Results: A detailed age and sex distribution analysis of BPPV onset showed that aging had a profound impact on BPPV occurrence in both sexes, and that perimenopausal women were especially susceptible to BPPV (3.2:1 female-to-male ratio). The latter is a novel finding and was confirmed by a direct survey of female BPPV patients (168 participated). In addition, there was a pronounced female preponderance (6.8:1 female-to-male ratio) in BPPV in the teenage group despite its low prevalence in this age group.

Conclusions: Data suggest that hormonal fluctuations (especially during menopause) may increase the tendency to develop BPPV.

From the 1Boys Town National Research Hospital, Omaha, NE; and 2Department of Otolaryngology, County Hospital, Krems, Austria.

Received September 11, 2013; revised and accepted November 14, 2013.

Funding/support: This work was supported by grants from the National Institutes of Health (R01DC008603, R01DC008603-S1, and P20GM103471 [formerly P20RR018788] pilot funding to Y.W.L., postdoctoral training grant T32DC000013 to O.A.O., and P20GM103471 pilot funding to E.S.C.) and by the Boys Town National Research Hospital.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Yunxia Wang Lundberg, PhD, Vestibular Genetics Laboratory, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131. E-mail:

© 2014 by The North American Menopause Society.