Skip Navigation LinksHome > April 2014 - Volume 21 - Issue 4 > Efficacy of exercise for menopausal symptoms: a randomized...
doi: 10.1097/GME.0b013e31829e4089
Original Articles

Efficacy of exercise for menopausal symptoms: a randomized controlled trial

Sternfeld, Barbara PhD1; Guthrie, Katherine A. PhD2; Ensrud, Kristine E. MD, MPH3; LaCroix, Andrea Z. PhD2; Larson, Joseph C. MS2; Dunn, Andrea L. PhD4; Anderson, Garnet L. PhD2; Seguin, Rebecca A. PhD5; Carpenter, Janet S. PhD, RN, FAAN6; Newton, Katherine M. PhD7; Reed, Susan D. MD, MPH8; Freeman, Ellen W. PhD9; Cohen, Lee S. MD10; Joffe, Hadine MD, MSc10; Roberts, Melanie MS11; Caan, Bette J. DrPH1

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Objective: This study aims to determine the efficacy of exercise training for alleviating vasomotor and other menopausal symptoms.

Methods: Late perimenopausal and postmenopausal sedentary women with frequent vasomotor symptoms (VMS) participated in a randomized controlled trial conducted in three sites: 106 women randomized to exercise and 142 women randomized to usual activity. The exercise intervention consisted of individual facility-based aerobic exercise training three times per week for 12 weeks. VMS frequency and bother were recorded on daily diaries at baseline and on weeks 6 and 12. Intent-to-treat analyses compared between-group differences in changes in VMS frequency and bother, sleep symptoms (Insomnia Severity Index and Pittsburgh Sleep Quality Index), and mood (Patient Health Questionnaire-8 and Generalized Anxiety Disorder-7 questionnaire).

Results: At the end of week 12, changes in VMS frequency in the exercise group (mean change, −2.4 VMS/d; 95% CI, −3.0 to −1.7) and VMS bother (mean change on a four-point scale, −0.5; 95% CI, −0.6 to −0.4) were not significantly different from those in the control group (−2.6 VMS/d; 95% CI, −3.2 to −2.0; P = 0.43; −0.5 points; 95% CI, −0.6 to −0.4; P = 0.75). The exercise group reported greater improvement in insomnia symptoms (P = 0.03), subjective sleep quality (P = 0.01), and depressive symptoms (P = 0.04), but differences were small and not statistically significant when P values were adjusted for multiple comparisons. Results were similar when considering treatment-adherent women only.

Conclusions: These findings provide strong evidence that 12 weeks of moderate-intensity aerobic exercise do not alleviate VMS but may result in small improvements in sleep quality, insomnia, and depression in midlife sedentary women.

© 2014 by The North American Menopause Society.


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