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Collagen cross-links as a marker for subclinical atherosclerosis in postmenopausal women

Caglar, Gamze Sinem MD1; Kahyaoglu, Inci MD1; Ozdemir, Elif Didem MD1; Seker, Rabia MD2; Demirtas, Selda MD2

doi: 10.1097/GME.0b013e318293761f
Original Articles

Objective: This study aimed to examine the utility of pyridinoline (Pyd) and deoxypyridinoline (Dpd) cross-links in the detection of subclinical atherosclerosis in postmenopausal women with or without osteoporosis.

Methods: We measured Pyd, Dpd, carotid intima-media thickness (CIMT), fasting total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and blood pressure in 59 healthy postmenopausal women: 30 had normal bone mineral density (group I) and the remaining 29 had osteoporosis or osteopenia (group II) according to World Health Organization criteria.

Results: There were no statistically significant differences in age, duration of menopause, age at menopause, lipid profile, body mass index, Pyd level, Dpd level, and Pyd-to-Dpd ratio between the groups (P > 0.05). No significant difference in CIMT was found when groups I and II were compared (P = 0.538). No statistically significant differences in Pyd level, Dpd level, and Pyd-to-Dpd ratio were found when women with CIMT higher than 5 mm and women with CIMT of 5 mm or less were compared in groups I and II (P > 0.05). However, significantly declined Dpd level and increased Pyd-to-Dpd ratio were found in women with CIMT higher than 5 mm when compared with women with CIMT of 5 mm or less. CIMT was found to be negatively correlated with Dpd level (r = −0.346, P = 0.007) and to be positively correlated with the Pyd-to-Dpd ratio (r = 0.702, P < 0.001).

Conclusions: The increase in the Pyd-to-Dpd ratio, irrespective of the participants’ bone mineral density, may have predictive value in the determination of subclinical atherosclerosis in postmenopausal women.

From the Departments of 1Obstetrics and Gynecology and 2Biochemistry, Faculty of Medicine, University of Ufuk, Ankara, Turkey.

Received November 26, 2012; revised and accepted March 18, 2013.

G.S.C. and E.D.O. collected, analyzed, and interpreted the data. I.K. contributed to data acquisition. G.S.C., I.K., and E.D.O. prepared the manuscript. S.D. and R.S. performed biochemical analyses on the serum and urine samples. All authors drafted and critically revised the manuscript for important intellectual content and approved the final version of the manuscript.

Funding/support: None.

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Gamze Sinem Caglar, MD, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ufuk, Mevlana Bulvarı Balgat, Ankara 06520, Turkey. E-mail: gamzesinem@hotmail.com

© 2014 by The North American Menopause Society.