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Association between polymorphisms in leptin, leptin receptor, and β-adrenergic receptor genes and bone mineral density in postmenopausal Korean women

Lee, Hee Jun MD1; Kim, Hoon MD, PhD1; Ku, Seung-Yup MD, PhD1,2; Choi, Young Min MD, PhD1,2; Kim, Jong Hak MD, PhD3; Kim, Jung Gu MD, PhD1,2

Erratum

In the article appearing in volume 21, pages 67–73, of Menopause, entitled “Association between polymorphisms in leptin, leptin receptor, and β-adrenergic receptor genes and bone mineral density in postmenopausal Korean women”, there was an error in the affiliation of the corresponding author, JH Kim. The university should have been listed as:

Ewha Womans University

Menopause. 21(4):433, April 2014.

doi: 10.1097/GME.0b013e31829366ed
Original Articles

Objective: The purpose of this study was to investigate the association between single nucleotide polymorphisms in leptin (LEP), leptin receptor (LEPR), and β-adrenergic receptor (ADRB) genes and bone mineral density (BMD) in postmenopausal Korean women.

Methods: LEP c.280G>A, LEPR c.326A>G, LEPR c.668A>G, LEPR c.1968G>C, LEPR c.2096C>T, ADRB2 c.46A>G, ADRB2 c.79C>G, ADRB2 c.718T>C, ADRB2 c.741G>T, ADRB2 c.769G>A, and ADRB3 c.190T>C polymorphisms were analyzed in 592 postmenopausal Korean women. Serum levels of leptin, soluble leptin receptor, osteoprotegerin, soluble receptor activator of the nuclear factor-κB ligand, bone alkaline phosphatase, and carboxy-terminal telopeptide of type I collagen were measured, and BMDs at the lumbar spine and femoral neck were also examined.

Results: Among the polymorphisms measured, only the LEPR c.1968G>C polymorphism was found to be associated with BMD at the femoral neck, and higher BMD was observed with increasing number of G alleles (P = 0.04). Osteoporosis at the femoral neck was 3.27 and 3.89 times more frequently observed in the AG and GG genotypes than in the AA genotype in the ADRB2 c.46A>G polymorphism (P = 0.024 and P = 0.015, respectively). However, no significant differences in serum levels of leptin, soluble leptin receptor, free leptin index, osteoprotegerin, soluble receptor activator of the nuclear factor-κB ligand, and bone turnover markers were detected among single and haplotype genotypes.

Conclusions: These results suggest that the LEPR c.1968G>C polymorphism may be one of the genetic factors affecting femoral neck BMD in postmenopausal Korean women and that an analysis of the ADRB2 c.46A>G polymorphism may be useful in identifying women at risk for osteoporosis at the femoral neck.

From the 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea; 2Clinical Research Institute, Seoul National University Hospital, Seoul, Korea; and 3Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Woman’s University, Seoul, Korea.

Received January 30, 2013; revised and accepted March 18, 2013.

J.H.K. and J.G.K. contributed equally to this work as corresponding authors.

Funding/support: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology (2011-0022334).

Financial disclosure/conflicts of interest: None reported.

Address correspondence to: Jung Gu Kim, MD, PhD, Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yeungun-dong, Chongno-gu, Seoul 110-744, Korea. E-mail: kimjg@plaza.snu.ac.kr; Jong Hak Kim, MD, PhD, Department of Anesthesiology and Pain Medicine, Ewha Woman’s University, Mokdong Hospital, 911, Mok-dong, Yangcheon-gu, Seoul 158-710, Korea. E-mail: kjhanes@ewha.ac.kr

© 2014 by The North American Menopause Society.